Health hazard · Specific target organ toxicity - single exposure
H335 — May cause respiratory irritation
Health hazard statements describe what the substance does to a person exposed to it. 230 substances with a harmonised EU classification carry this code.
EU CLP: currentUS OSHA HazCom: currentUS HazCom 2012: currentUN GHS: current
01 · Wording
What H335 says
Official
May cause respiratory irritation.
Source
CLP Annex III · Health hazards
Classification 
Specific target organ toxicity - single exposure GHS chapter 3.8
Category 3 · pictogram GHS07 (exclamation mark) · signal word Warning
UN GHS history
Unchanged since 2009.
Rev.3 2009
Rev.4 2011
Rev.5 2013
Rev.6 2015
Rev.7 2017
Rev.8 2019
Rev.9 2021
Rev.10 2023
Rev.11 2025
wording never changed
Present in every UN GHS edition from Rev.3 (2009) to Rev.11 (2025), with the same wording throughout.
Nine editions of the UN model text, 86 hazard statements, 19 of which ever moved. Read the full story in what changed in UN GHS Rev.11.
02 · Legal status
Where H335 is current
GHS is a United Nations model text, revised every two years, and each jurisdiction adopts a revision on its own timetable. A code can be legally current in one system and deleted in another — that is normal, not an error.
| Jurisdiction | Basis | Status of H335 |
|---|---|---|
| EU CLP | Regulation (EC) 1272/2008 CLP Annex IV, Part 2 (consolidated) | Current |
| US OSHA HazCom | 29 CFR 1910.1200 Appendix C UN GHS Rev.7 (final rule of 20 May 2024) | Current |
| US HazCom 2012 | legacy · GHS Rev.3 UN GHS Rev.3, Annex 3 | Current |
| UN GHS | Rev.11 (2025) UN GHS Rev.11, Annex 3 | Current |
Currently in force under: EU CLP, US OSHA HazCom, US HazCom 2012, UN GHS. Sources: EU CLP · US OSHA HazCom · US HazCom 2012 · UN GHS
03 · Substances
Substances carrying H335
Every entry whose harmonised CLP Annex VI classification includes this hazard statement. Substances with a reference page here open on this site; the rest open on ghssymbols.com. Of these, 12 are group entries such as “salts of picric acid” or “beryllium compounds” — Annex VI gives them no CAS number, so they are listed by Index No and have no page of their own.
- (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate CAS 42978-66-5
- (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone CAS 83-79-4
- (Z)-octadec-9-enylamine CAS 112-90-3
- 1-bromopropane; n-propyl bromide CAS 106-94-5
- 1-naphtol CAS 90-15-3
- 1-pentanol [1]; 3-pentanol [2] CAS 71-41-0[1]584-02-1[2
- 1-vinyl-2-pyrrolidone CAS 88-12-0
- 1,1-dichloroethane CAS 75-34-3
- 1,2-dibromoethane CAS 106-93-4
- 1,2-dichlorobenzene; o-dichlorobenzene CAS 95-50-1
- 1,2-dichloroethane; ethylene dichloride CAS 107-06-2
- 1,2-epoxybutane CAS 106-88-7
- 1,2,4-trimethylbenzene CAS 95-63-6
- 1,3-dichloropropene [1]; (Z)-1,3-dichloropropene [2] CAS 542-75-6[1]10061-01-
- 1,3-diphenylguanidine CAS 102-06-7
- 1,3,5-trioxan; trioxymethylene CAS 110-88-3
- 1,4-dioxane CAS 123-91-1
- 1,4,5,6,7,7-hexachlorobicyclo [2,2,1]hept-5-ene-2,3-dicarboxylic anhydride chlorendic anhydride CAS 115-27-5
- 1,4,7,10-tetraazacyclododecane disulfate CAS 112193-77-8
- 1,5-naphthylene diisocyanate; [containing < 0.1 % (w/w) of particles with an aerodynamic diameter of below 50 µm] CAS 3173-72-6
- 2-aminopropane; isopropylamine CAS 75-31-0
- 2-ethylhexyl acrylate CAS 103-11-7
- 2-furaldehyde CAS 98-01-1
- 2-methoxypropanol CAS 1589-47-5
- 2-methoxypropyl acetate CAS 70657-70-4
- 2-methylbutan-2-ol; tert-pentanol CAS 75-85-4
- 2-methylpropan-1-ol; iso-butanol CAS 78-83-1
- 2-methylpropan-2-ol; tert-butyl alcohol CAS 75-65-0
- 2-methylpyridine; 2-picoline CAS 109-06-8
- 2-phenoxyethanol CAS 122-99-6
- 2-phenylpropene; α-methylstyrene CAS 98-83-9
- 2,2,4-trimethylhexamethylene-1,6-di-isocyanate [1]; 2,4,4-trimethylhexamethylene-1,6-di-isocyanate [2] CAS 16938-22-0[1]15646-9
- 2,3-dichloropropene; 2,3-dichloropropylene CAS 78-88-6
- 2,3-epoxypropan-1-ol; glycidol; oxiranemethanol CAS 556-52-5
- 2,3-epoxypropyl methacrylate; glycidyl methacrylate CAS 106-91-2
- 2,3,4-trichlorobut-1-ene CAS 2431-50-7
- 2,3,5-trimethylhydroquinone CAS 700-13-0
- 2,4-D (ISO); 2,4-dichlorophenoxyacetic acid CAS 94-75-7
- 2,4-dichloro-5-fluorobenzoylchloride CAS 86393-34-2
- 2,4,5-T (ISO); 2,4,5-trichlorophenoxy acetic acid CAS 93-76-5
- 2,6-dimethylheptan-4-one; di-isobutyl ketone CAS 108-83-8
- 2,6-xylidine; 2,6-dimethylaniline CAS 87-62-7
- 3-chloropropene; allyl chloride CAS 107-05-1
- 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate; isophorone di-isocyanate CAS 4098-71-9
- 3,5,5-trimethylcyclohex-2-enone; isophorone CAS 78-59-1
- 3a,4,7,7a-tetrahydro-4,7-methanoindene CAS 77-73-6
- 4-chlorophenylisocyanate CAS 104-12-1
- 4-isocyanatosulphonyltoluene; tosyl isocyanate CAS 4083-64-1
- 4-methyl-N-(methylsulfonyl)benzenesulfonamide CAS 14653-91-9
- 4-methylpentan-2-ol; methyl isobutyl carbinol CAS 108-11-2
- 4-methylpyridine; 4-picoline CAS 108-89-4
- 4,4'-methylenedi(cyclohexyl isocyanate); dicyclohexylmethane-4,4'-di-isocyanate CAS 5124-30-1
- 5-methylheptan-3-one CAS 541-85-5
- 8,9-dinorborn-5-ene-2,3-dicarboxylic anhydride CAS 123748-85-6
- acetaldehyde;; ethanal CAS 75-07-0
- acetochlor (ISO); 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide CAS 34256-82-1
- acibenzolar-S-methyl; benzo[1,2,3]thiadiazole-7-carbothioic acid S-methyl ester CAS 135158-54-2
- acrylonitrile CAS 107-13-1
- allyl alcohol CAS 107-18-6
- allyl glycidyl ether; allyl 2,3-epoxypropyl ether; prop-2-en-1-yl 2,3-epoxypropyl ether CAS 106-92-3
- amines, coco alkyl CAS 61788-46-3
- azocyclotin (ISO); 1-(tricyclohexylstannyl)-1H-1,2,4-triazole CAS 41083-11-8
- barium polysulphides CAS 50864-67-0
- benomyl (ISO); methyl 1-(butylcarbamoyl)benzimidazol-2-ylcarbamate CAS 17804-35-2
- benzene-1,2,4-tricarboxylic acid 1,2-anhydride; trimellitic anhydride CAS 552-30-7
- benzophenone-3,3',4,4'-tetracarboxylic dianhydride; 4,4'-carbonyldi(phthalic anhydride) CAS 2421-28-5
- beryllium CAS 7440-41-7
- beryllium compounds with the exception of aluminium beryllium silicates, and with those specified elsewhere in this Annex Index No 004-002-00-2
- beryllium oxide CAS 1304-56-9
- biphenyl; diphenyl CAS 92-52-4
- bis(piperidinothiocarbonyl) disulphide CAS 94-37-1
- bisphenol A CAS 80-05-7
- bromelain, juice CAS 9001-00-7
- bromomethane; methylbromide CAS 74-83-9
- bronopol (INN); 2-bromo-2-nitropropane-1,3-diol CAS 52-51-7
- butan-1-ol; n-butanol CAS 71-36-3
- butan-2-ol [1]; (S)-butan-2-ol [2]; (R)-butan-2-ol [3]; (±)-butan-2-ol [4] CAS 78-92-2[1]4221-99-2[
- butyl formate [1]; tert-butyl formate [2]; isobutyl formate [3] CAS 592-84-7[1]762-75-4[
- butyl glycidyl ether; butyl 2,3-epoxypropyl ether CAS 2426-08-6
- calcium cyanamide CAS 156-62-7
- calcium polysulphides CAS 1344-81-6
- calcium sulphide CAS 20548-54-3
- camphechlor (ISO); toxaphene CAS 8001-35-2
- chlorine CAS 7782-50-5
- chlorocresol;; 4-chloro-m-cresol;; 4-chloro-3-methylphenol CAS 59-50-7
- chloroprene (stabilised); 2-chlorobuta-1,3-diene (stabilised) CAS 126-99-8
- chlorosulphonic acid CAS 7790-94-5
- chlorothalonil (ISO); tetrachloroisophthalonitrile CAS 1897-45-6
- chymotrypsin CAS 9004-07-3
- citric acid CAS 77-92-9
- crotonaldehyde; 2-butenal [1]; (E)-2-butenal; (E)-crotonaldehyde [2] CAS 4170-30-3[1]123-73-9
- Cumene CAS 98-82-8
- cyclohexanol CAS 108-93-0
- cyclohexyl acrylate CAS 3066-71-5
- cyclopentane-1,2,3,4-tetracarboxylic dianhydride CAS 6053-68-5
- cypermethrin (ISO);; α-cyano-3-phenoxybenzyl 3-(2,2-dichlorovi-nyl)-2,2-dimethylcyclopro-panecarboxylate; cypermethrin cis/trans +/- 40/60 CAS 52315-07-8
- di-n-butyl ether; dibutyl ether CAS 142-96-1
- diammonium peroxodisulphate; ammonium persulphate CAS 7727-54-0
- dicamba (ISO); 2,5-dichloro-6-methoxybenzoic acid; 3,6-dichloro-2-methoxybenzoic acid CAS 1918-00-9
- dichloro-1,3,5-triazinetrione; dichloroisocyanuric acid CAS 2782-57-2
- diethylcarbamoyl chloride CAS 88-10-8
- dimercury dichloride; mercurous chloride; calomel CAS 10112-91-1
- dimethylcarbamoyl chloride CAS 79-44-7
- dimethyldichlorosilane CAS 75-78-5
- dipotassium peroxodisulphate; potassium persulphate CAS 7727-21-1
- diquat dibromide [1]; diquat dichloride [2]; 6,7-dihydrodipyrido[1,2-α:2',1'-c]pyrazinediylium dihydroxide [3] CAS 85-00-7[1]4032-26-2[
- disodium metasilicate CAS 6834-92-0
- divanadium pentaoxide; vanadium pentoxide CAS 1314-62-1
- dodecyl methacrylate CAS 142-90-5
- endothal (ISO); 7-oxabicyclo(2,2,1)heptane-2,3-dicarboxylic acid CAS 145-73-3
- endothal-sodium (ISO); disodium 7-oxabicyclo(2,2,1)heptane-2,3-dicarboxylate CAS 129-67-9
- ethyl 2-cyanoacrylate CAS 7085-85-0
- ethyl acrylate CAS 140-88-5
- ethyl formate CAS 109-94-4
- ethyl lactate; ethyl DL-lactate [1]; ethyl (S)-2-hydroxypropionate; ethyl L-lactate; ethyl-(S)-lactate [2] CAS 97-64-3[1]687-47-8[2
- ethyl methacrylate CAS 97-63-2
- ethylamine CAS 75-04-7
- ethylene dimethacrylate CAS 97-90-5
- ethylene oxide CAS 75-21-8
- fenpropidin (ISO); (R,S)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine CAS 67306-00-7
- fentin acetate (ISO); triphenyltin acetate CAS 900-95-8
- fentin hydroxide (ISO); triphenyltin hydroxide CAS 76-87-9
- ferbam (ISO); iron tris(dimethyldithiocarbamate) CAS 14484-64-1
- ficin CAS 9001-33-6
- furfuryl alcohol CAS 98-00-0
- glutaraldehyde CAS 111-30-8
- guazatine (ISO) CAS 108173-90-6
- hexafluoropropene; hexafluoropropylene CAS 116-15-4
- hexamethylene-di-isocyanate CAS 822-06-0
- hexamethylenediamine CAS 124-09-4
- hexyl acrylate CAS 2499-95-8
- hydrobromic acid ... % Index No 035-002-01-8
- hydrochloric acid ... % Index No 017-002-01-X
- hydrogen bromide CAS 10035-10-6
- hydroxylamine ....% [> 55 % in aqueous solution] CAS 7803-49-8
- isobutyl methacrylate CAS 97-86-9
- isooctyl acrylate CAS 29590-42-9
- isopentyl formate [1]; pentyl formate [2] CAS 110-45-2[1]35073-27-
- isopropyl chloroacetate CAS 105-48-6
- maleic acid CAS 110-16-7
- mecrilate; methyl 2-cyanoacrylate CAS 137-05-3
- mesitylene; 1,3,5-trimethylbenzene CAS 108-67-8
- methyl acrylate; methyl propenoate CAS 96-33-3
- methyl chloroacetate CAS 96-34-4
- methyl formate CAS 107-31-3
- methyl iodide; iodomethane CAS 74-88-4
- methyl isocyanate CAS 624-83-9
- methyl lactate [1]; methyl (±)-lactate [2]; methyl (R)-lactate [3]; methyl (S)-(-)-lactate [4] CAS 547-64-8[1]2155-30-8
- methyl methacrylate CAS 80-62-6
- methylene diphenyl diisocyanate CAS 101-68-8[1]2536-05-2
- molybdenum trioxide CAS 1313-27-5
- mono-methylamine [1]; di-methylamine [2]; tri-methylamine [3] CAS 74-89-5[1]124-40-3[2
- monoalkyl or monoaryl or monoalkyaryl esters of methacrylic acid with the exception of those specified elsewhere in this Annex Index No 607-134-00-4
- monoalkyl or monoaryl or monoalkylaryl esters of acrylic acid with the exception of those specified elsewhere in this Annex Index No 607-133-00-9
- morfamquat (ISO); 1,1'-bis(3,5-dimethylmorpholinocarbonylmethyl)-4,4'-bipyridilium ion CAS 7411-47-4
- morfamquat dichloride [1]; morfamquat sulfate [2] CAS 4636-83-3[1]29873-36
- n-butyl acrylate CAS 141-32-2
- n-butyl methacrylate CAS 97-88-1
- N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone CAS 872-50-4
- nabam (ISO); disodium ethylenebis(N,N'-dithiocarbamate) CAS 142-59-6
- oleum ... % SO3 Index No 016-019-00-2
- p-benzoquinone; quinone CAS 106-51-4
- p-toluenesulphonic acid (containing a maximum of 5 % H2SO4) CAS 104-15-4
- papain CAS 9001-73-4
- paraquat dichloride; 1,1-dimethyl-4,4'-bipyridinium dichloride [1]; paraquat dimethylsulfate; 1,1-dimethyl-4,4'-bipyridinium dimethyl sulphate [2] CAS 1910-42-5[1]2074-50-
- pentachlorophenol CAS 87-86-5
- pentan-3-one; diethyl ketone CAS 96-22-0
- pentanol isomers, with the exception fo those specified elsewhere in this Annex Index No 603-006-00-7
- pentyl formate CAS 638-49-3
- pepsin A CAS 9001-75-6
- perboric acid (H 3 BO 2(O2 )),; monosodium salt trihydrate [1]; perboric acid, sodium salt, tetrahydrate [2]; perboric acid (HBO(O 2 )), sodium salt, tetrahydrate [3]; sodium peroxoborate, hexahydrate [4] CAS 13517-20-9[1]37244-9
- perboric acid, sodium salt [1]; perboric acid, sodium salt, monohydrate [2]; perboric acid (HBO(O 2 )), sodium salt, monohydrate [3] ; sodium peroxoborate [4]; sodium perborate [5] CAS 11138-47-9[1]12040-7
- phenyl glycidyl ether; 2,3-epoxypropyl phenyl ether; 1,2-epoxy-3-phenoxypropane CAS 122-60-1
- phosphorus tribromide CAS 7789-60-8
- phthalic anhydride CAS 85-44-9
- pinoxaden (ISO);; 8-(2,6-diethyl-4-methylphenyl)-7-oxo-1,2,4,5-tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin-9-yl 2,2-dimethylpropanoate CAS 243973-20-8
- piperonyl butoxide (ISO); 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether CAS 51-03-6
- poly-[((4-((4-(ethyl-ethylene)amino)phenyl)-(4-(ethyl-(2-oxyethylene)amino)phenyl)methinyl)-3-methylcyclohexa-2,5-dienylidene)-N-ethyl-N-(2-hydroxyethyl)ammonium acetate] CAS 176429-22-4
- poly-[((4-((4-ethyl-ethylene)amino)phenyl)-((4-(ethyl-(2-oxyethylene)amino)phenyl)methinyl)cyclohexa-2,5-dienylidene)-N-ethyl-N-(2-hydroxyethyl)ammonium acetate] CAS 176429-27-9
- potassium 2-hydroxycarbazole-1-carboxylate CAS 96566-70-0
- potassium chromate CAS 7789-00-6
- potassium hydrogensulphate CAS 7646-93-7
- propanal; propionaldehyde CAS 123-38-6
- propyl formate [1]; isopropyl formate [2] CAS 110-74-7[1]625-55-8[
- Propylbenzene CAS 103-65-1
- propylene oxide; 1,2-epoxypropane; methyloxirane CAS 75-56-9
- proteases with the exception of those specified elsewhere in this Annex Index No 647-014-00-9
- proteinase, microbial neutral CAS 9068-59-1
- pyraclostrobin (ISO); methyl N-{2-[1-(4-chlorophenyl)-1H-pyrazol-3-yloxymethyl]phenyl}(N-methoxy)carbamate CAS 175013-18-0
- reaction product of amorphous silica (50-85 %), butyl (1-methylpropyl) magnesium (3-15 %), tetraethyl orthosilicate (5-15 %) and titanium tetrachloride (5-20 %) Index No 014-043-00-8
- rennin CAS 9001-98-3
- sabadilla (ISO); veratrine CAS 8051-02-3
- salts and esters of 2,4,5-T; salts and esters of 2,4,5-trichlorophenoxy acetic acid Index No 607-042-00-4
- silicon tetrachloride CAS 10026-04-7
- sodium 2-biphenylate; 2-phenylphenol, sodium salt CAS 132-27-4
- sodium 4-(2,4,4-trimethylpentylcarbonyloxy)benzenesulfonate Index No 016-054-00-3
- sodium N-(hydroxymethyl)glycinate; [formaldehyde released from sodium N-(hydroxymethyl)glycinate] CAS 70161-44-3
- sodium pentachlorophenolate [1]; potassium pentachlorophenolate [2] CAS 131-52-2[1]7778-73-6
- sodium peroxometaborate CAS 7632-04-4
- spirotetramat (ISO); (5s,8s)-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4,5]dec-3-en-4-yl ethyl carbonate CAS 203313-25-1
- subtilisin CAS 9014-01-1
- sulphur dichloride CAS 10545-99-0
- sulphuryl chloride CAS 7791-25-5
- symclosene; trichloroisocyanuric acid; trichloro-1,3,5-triazinetrion CAS 87-90-1
- TCA-sodium (ISO); sodium trichloroacetate CAS 650-51-1
- tert-butyl acrylate CAS 1663-39-4
- tetraethyl silicate; ethyl silicate CAS 78-10-4
- tetrahydrofuran CAS 109-99-9
- tetrahydrofuran-2,5-diyldimethanol CAS 104-80-3
- thiocarbonyl chloride CAS 463-71-8
- toluene diisocyanate CAS 91-08-7[1]584-84-9[2
- tolylfluanid (ISO); dichloro-N- [(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide; [containing ≥ 0.1 % (w/w) of particles with an aerodynamic diameter of below 50 µm] CAS 731-27-1
- trichloro(methyl)silane; methyltrichlorosilane CAS 75-79-6
- trichloronitromethane; chloropicrin CAS 76-06-2
- trioctyltin compounds, with the exception of those specified elsewhere in this Annex Index No 050-013-00-0
- troclosene potassium [1]; troclosene sodium [2] CAS 2244-21-5[1]2893-78-
- troclosene sodium, dihydrate CAS 51580-86-0
- trypsin CAS 9002-07-7
- vinyl acetate CAS 108-05-4
- zinc bis(dibutyldithiocarbamate) CAS 136-23-2
- zinc bis(diethyldithiocarbamate) CAS 14324-55-1
- zineb (ISO); zinc ethylenebis(dithiocarbamate) (polymeric) CAS 12122-67-7
- ziram (ISO); zinc bis dimethyldithiocarbamate CAS 137-30-4
- α-bromotoluene; benzyl bromide CAS 100-39-0
- α-chlorotoluene; benzyl chloride CAS 100-44-7
- α-cypermethrin (ISO); racemate comprising (R)-α-cyano-3-phenoxybenzyl (1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; (S)-α-cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate CAS 67375-30-8
- α, α,α,4-tetrachlorotoluene; p-chlorobenzotrichloride CAS 5216-25-1
- α,α-dichlorotoluene; benzylidene chloride; benzal chloride CAS 98-87-3
- α,α,α-trichlorotoluene; benzotrichloride CAS 98-07-7
- ε-caprolactam CAS 105-60-2
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All hazard statements
The full list of H-codes with the jurisdiction switch lives on the hazard statements hub. For what to do about the hazard, see precautionary statements (P-codes).
Wording quoted from the regulation named above. Substance counts come from harmonised classifications in CLP Annex VI — the statements on a real product also depend on the supplier's own classification. Always check the supplier safety data sheet.