Substance profile
4-Chlorophenyl Isocyanate
4-Chlorophenyl Isocyanate is colorless to slightly yellow liquid or crystals.
01 · Identification
What 4-Chlorophenyl Isocyanate is
4-Chlorophenyl Isocyanate is colorless to slightly yellow liquid or crystals. Its molecular formula is C7H4ClNO and its molecular weight is 153.56 g/mol. It boils at 204 °C, melts at 31.3 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
Other names for 4-Chlorophenyl Isocyanate
- 4-chlorophenylisocyanate
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H330 | Fatal if inhaled. |
| H302 | Harmful if swallowed. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H318 | Causes serious eye damage. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Precautionary statements: P260, P264, P270, P271, P273, P280, P301, P302, P304, P305, P310, P312, P313, P330, P332, P338, P352, P391, P501, P201, P261, P284, P340, P342, P311
03 · Physical and chemical properties
4-Chlorophenyl Isocyanate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 204 °C (399.2 °F) | HSDB | |
| 116 °C (240.8 °F) | at 45 mmHg (reduced pressure) | HSDB | |
| Melting point | 31.3 °C (88.3 °F) | HSDB | |
| Density | 1.25 g/cm³ | at 40 °C | HSDB |
| Solubility | Soluble in organic solvents | HSDB | |
| Vapor pressure | 95.4 mmHg | at 20 °C | HSDB |
| 19.4 mmHg | at 25 °C, extrapolated | HSDB | |
| 95.4 mmHg | Haz-Map | ||
| Flash point | 110 °C (230 °F) | HSDB | |
| Lower explosive limit (LEL) | Can explode on distillation. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling 4-Chlorophenyl Isocyanate
Storage conditions
Isocyanates are transported in railroad tank cars, tank trucks, tanks in ships, containers, and drums. They are stored in steel tanks and processed in steel equipment. For long-term storage stainless steel is recommended. To avoid contamination by atmospheric moisture, a dry air or inert gas blanket is essential. /Isocyanates/
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Chlorophenyl Isocyanate in the storage compatibility matrix →