Calculator · Acute toxicity estimate
ATE Mixture Calculator
Classify a chemical mixture for acute toxicity under GHS / CLP. Add ingredients from a 4,000-substance database — the calculator auto-fills each ATE from its harmonised Annex VI classification, runs the additivity formula across oral, dermal and inhalation routes, and returns the category, H-statements, pictogram and a printable report.
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How the classification works
1 · Resolve each ATE
Every ingredient gets an acute toxicity estimate: a measured LD50/LC50 value where one exists, otherwise the converted point estimate from its harmonised category (GHS Table 3.1.2). You can override any value.
2 · Apply the additivity formula
For each route, 100 / ATEmix = Σ(Ci / ATEi) over ingredients ≥ 1%. If unknown-toxicity ingredients exceed 10%, the numerator is corrected to (100 − ΣCunknown).
3 · Assign the category
ATEmix is placed on the Table 3.1.1 cut-offs to give a hazard category per route, then the worst category sets the signal word, pictogram (GHS06 / GHS07) and H-statements.
Reference: UN GHS Chapter 3.1 (acute toxicity) and CLP Annex I 3.1.3 (classification of mixtures). Converted point estimates follow Table 3.1.2; cut-off ranges follow Table 3.1.1. This tool is a computed aid for SDS authoring — always review the outcome against each ingredient's safety data sheet and Annex VI entry.
Frequently asked questions
What is the ATE mixture formula?
The acute toxicity estimate of a mixture is calculated with the GHS additivity formula: 100 / ATEmix = Σ (Ci / ATEi), summed over every ingredient present at ≥ 1% that has a known ATE. Ci is the ingredient concentration in weight-% and ATEi is that ingredient's acute toxicity estimate (a measured LD50/LC50 point estimate, or the converted value from its classification category). The result is compared against the Table 3.1.1 cut-offs to assign a hazard category per route.
How does the calculator handle ingredients without a measured LD50?
When an ingredient has no numeric ATE but carries a harmonised acute-toxicity hazard statement (H300–H332), the tool converts its classification category to a point estimate using GHS Table 3.1.2 — for example oral Category 3 → 100 mg/kg, inhalation vapour Category 1 → 0.05 mg/L. This is the method GHS prescribes for mixture classification and it lets the calculator work across the whole substance database, not only the chemicals with a published numeric ATE.
What is the 10% unknown-toxicity rule?
If ingredients whose acute toxicity is unknown add up to more than 10% of the mixture, the numerator of the additivity formula is reduced to (100 − ΣCunknown) so the estimate is based only on the classified fraction. At or below 10%, the unknown ingredients are disregarded and the full 100 is used. The calculator applies this correction automatically and flags any route where it fired.
Which routes and inhalation forms are covered?
Oral and dermal (mg/kg body weight) plus inhalation. Because a hazard statement like H330 does not encode the physical form, you choose whether the mixture is inhaled as a gas (ppmV), a vapour (mg/L) or a dust/mist (mg/L); the inhalation route then uses that column's cut-offs and converted point estimates from Tables 3.1.1 and 3.1.2.
Is this the same as an LD50 calculator?
No. An LD50 calculator fits a dose–response curve to experimental mortality data to estimate the median lethal dose of a single substance. This tool takes the LD50/LC50-derived ATE of each ingredient and combines them into the acute toxicity estimate of the whole mixture for GHS/CLP labelling. Use an LD50 tool to get a single substance's value, then bring that value here to classify a formulation.
Working from a single substance?
Look up harmonised classification, storage compatibility and transport data for one chemical in the SDS library, check what a formulation can be stored next to with the storage compatibility matrix, or browse every free GHS tool.