Substance profile
4,4'-methylenedi(cyclohexyl isocyanate)
4,4'-methylenedi(cyclohexyl isocyanate) is a clear, colorless to light-yellow liquid.
01 · Identification
What 4,4'-methylenedi(cyclohexyl… is
4,4'-methylenedi(cyclohexyl isocyanate) is a clear, colorless to light-yellow liquid. Its molecular formula is C15H22N2O2 and its molecular weight is 262.35 g/mol. It melts at -10 °C, is soluble in water.
Under the GHS it carries the signal word Danger.
Other names for 4,4'-methylenedi(cyclohexyl…
- dicyclohexylmethane-4,4'-di-isocyanate
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H331 | Toxic if inhaled. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| H317 | May cause an allergic skin reaction. |
Precautionary statements: P260, P261, P264, P271, P272, P280, P302, P304, P305, P310, P313, P332, P333, P337, P338, P352
03 · Physical and chemical properties
4,4'-methylenedi(cyclohexyl… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | -10 °C (14 °F) | below this value | NIOSH |
| Density | 1.066 g/cm³ | HSDB | |
| 1.07 g/cm³ | at 25 °C | CAMEO | |
| Solubility | Soluble in acetone | HSDB | |
| Reacts | NIOSH | ||
| Reacts with water (NIOSH, 2024) | CAMEO | ||
| Vapor pressure | 0.001 mmHg | at 25 °C | HSDB |
| Flash point | 201.67 °C (395 °F) | above this value | NIOSH |
| Lower explosive limit (LEL) | Class IIIB Combustible Liquid: Fl.P. at or above 200 °F. | NIOSH |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling 4,4'-methylenedi(cyclohexyl…
Incompatible materials
Substance reacts with water. ...Dicyclohexylmethan-4,4'-diisocyanate reacts in comparison to hexamethylene diisocyanate very slowly with water and slowly with alcohols or amines; normally the reaction must be catalyzed with metal compounds.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
Isocyanates and thioisocyanates, such as 1,1-METHYLENE BIS(4-ISOCYANATOCYCLOHEXANE), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence [Wischmeyer(1969)].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4,4'-methylenedi(cyclohex… in the storage compatibility matrix →