Substance profile
(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone
(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone is orthorhombic, six-sided plates from trichloroethylene and is odorless.
01 · Identification
What (2R,6aS,12aS)-1,2,6,6a,12,12a… is
(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone is orthorhombic, six-sided plates from trichloroethylene and is odorless. It boils at 215 °C, melts at 176 °C, is slightly soluble in water.
Under the GHS it carries the signal word Danger.
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H301 | Toxic if swallowed. |
| H335 | May cause respiratory irritation. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Precautionary statements: P264, P270, P273, P280, P301, P302, P305, P310, P313, P330, P332, P337, P338, P352, P391, P501
03 · Physical and chemical properties
(2R,6aS,12aS)-1,2,6,6a,12,12a… properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 215 °C (419 °F) | range, midpoint shown | OSHA |
| 215 °C (419 °F) | at 0.5 mmHg (reduced pressure) | HSDB | |
| 215 °C (419 °F) | range, midpoint shown, at 0.5 mmHg (reduced pressure) | CAMEO | |
| Melting point | 176 °C (348.8 °F) | HSDB | |
| 165.56 °C (330 °F) | NIOSH | ||
| Density | 1.27 g/cm³ | NIOSH | |
| 1.27 g/cm³ | at 20 °C | HSDB | |
| Solubility | Soluble in ethanol, acetone, benzene; slightly soluble in ether; very soluble in chloroform | HSDB | |
| SLIGHTLY SOLUBLE IN PETROLEUM OILS | HSDB | ||
| SOL IN LIPIDS | HSDB | ||
| Vapor pressure | 0.0008 mmHg | at 20 °C | DOE PAC |
| 0.00004 mmHg | below this value | NIOSH | |
| 0.0075 mmHg | below this value, at 20 °C | CAMEO | |
| Lower explosive limit (LEL) | Combustible Solid | NIOSH | |
| Corrosivity | Non-corrosive | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling (2R,6aS,12aS)-1,2,6,6a,12,12a…
Storage conditions
Store only in original containers, in a dry place inaccessible to children and pets. /7.4% Rotenone Wettable Powder/
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Strong oxidizers, alkalis.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
ROTENONE is readily oxidized in the presence of alkalis. It is incompatible with oxidizers. (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check (2R,6aS,12aS)-1,2,6,6a,12… in the storage compatibility matrix →