Health hazard · Acute toxicity - oral
H300 — Fatal if swallowed
Health hazard statements describe what the substance does to a person exposed to it. 160 substances with a harmonised EU classification carry this code.
01 · Wording
What H300 says
Fatal if swallowed.
CLP Annex III · Health hazards
Acute toxicity - oral GHS chapter 3.1
Category 2, 1 · pictogram GHS06 (skull and crossbones) · signal word Danger
Unchanged since 2009.
Present in every UN GHS edition from Rev.3 (2009) to Rev.11 (2025), with the same wording throughout.
Nine editions of the UN model text, 86 hazard statements, 19 of which ever moved. Read the full story in what changed in UN GHS Rev.11.
02 · Legal status
Where H300 is current
GHS is a United Nations model text, revised every two years, and each jurisdiction adopts a revision on its own timetable. A code can be legally current in one system and deleted in another — that is normal, not an error.
| Jurisdiction | Basis | Status of H300 |
|---|---|---|
| EU CLP | Regulation (EC) 1272/2008 CLP Annex IV, Part 2 (consolidated) | Current |
| US OSHA HazCom | 29 CFR 1910.1200 Appendix C UN GHS Rev.7 (final rule of 20 May 2024) | Current |
| US HazCom 2012 | legacy · GHS Rev.3 UN GHS Rev.3, Annex 3 | Current |
| UN GHS | Rev.11 (2025) UN GHS Rev.11, Annex 3 | Current |
Currently in force under: EU CLP, US OSHA HazCom, US HazCom 2012, UN GHS. Sources: EU CLP · US OSHA HazCom · US HazCom 2012 · UN GHS
03 · On a label
H300 also appears combined
CLP Annex III defines combined hazard statements as single label elements. H300 is a component of 3 of them — this is how you will actually see it printed. The combinations have no pages of their own: a plus sign in a URL has to be encoded and breaks in other people's links and in analytics.
| Code | Combined statement |
|---|---|
| H300+H310 | Fatal if swallowed or in contact with skin. CLP verbatim: Fatal if swallowed or in contact with skin |
| H300+H330 | Fatal if swallowed or if inhaled. CLP verbatim: Fatal if swallowed or if inhaled |
| H300+H310+H330 | Fatal if swallowed, in contact with skin or if inhaled. CLP verbatim: Fatal if swallowed, in contact with skin or if inhaled |
04 · Substances
Substances carrying H300
Every entry whose harmonised CLP Annex VI classification includes this hazard statement. Substances with a reference page here open on this site; the rest open on ghssymbols.com. Of these, 17 are group entries such as “salts of picric acid” or “beryllium compounds” — Annex VI gives them no CAS number, so they are listed by Index No and have no page of their own.
- (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;; medetomidine CAS 86347-14-0
- [(dimethylsilylene)bis((1,2,3,3a,7a-η)-1H-inden-1-ylidene)dimethyl]hafnium CAS 137390-08-0
- 1-(3,4-dichlorophenylimino) thiosemicarbazide CAS 5836-73-7
- 1-isopropyl-3-methylpyrazol-5-yl dimethylcarbamate; Isolan CAS 119-38-0
- 1,3,5-trinitrobenzene CAS 99-35-4
- 2-chloro-1,3,5-trinitrobenzene CAS 88-88-0
- 2-chloroethanol; ethylene chlorohydrin CAS 107-07-3
- 2-fluoroacetamide CAS 640-19-7
- 2-hydroxy-2-methylpropionitrile; 2-cyanopropan-2-ol; acetone cyanohydrin CAS 75-86-5
- 2-methylaziridine; propyleneimine CAS 75-55-8
- 2-nitro-p-anisidine; 4-methoxy-2-nitroaniline CAS 96-96-8
- 2,4-dinitroaniline CAS 97-02-9
- 2,4-dinitrophenol CAS 51-28-5
- 3-(3-amino-5-(1-methylguanidino)-1-oxopentylamino-6-(4-amino-2-oxo-2,3-dihydro-pyrimidin-1-yl)-2,3-dihydro-(6H)-pyran-2-carboxylic acid; blasticidin-s CAS 2079-00-7
- 3-chloro-6-cyano-bicyclo(2,2,1)heptan-2-one-O-(N-methylcarbamoyl)oxime; triamid CAS 15271-41-7
- abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]; avermectin B1a (purity ≥80 %) [2] CAS 71751-41-2[1]65195-5
- aconitine CAS 302-27-2
- acrolein; prop-2-enal; acrylaldehyde CAS 107-02-8
- aldicarb (ISO); 2-methyl-2-(methylthio)propanal-O-(N-methylcarbamoyl)oxime CAS 116-06-3
- aluminium phosphide CAS 20859-73-8
- ammonium salt of DNOC; ammonium 4,6-dinitro-o-tolyl oxide CAS 2980-64-5
- antu (ISO); 1-(1-naphthyl)-2-thiourea CAS 86-88-4
- atropine CAS 51-55-8
- azinphos-ethyl (ISO); O,O-diethyl 4-oxobenzotriazin-3-ylmethyl phosphorodithioate CAS 2642-71-9
- azinphos-methyl (ISO); O,O-dimethyl-4-oxobenzotriazin-3-ylmethyl phosphorodithioate CAS 86-50-0
- bendiocarb (ISO); 2,2-dimethyl-1,3-benzodioxol-4-yl N-methylcarbamate; 2,2-dimethyl-1,3-benzodioxol-4-yl methylcarbamate CAS 22781-23-3
- beta-cyfluthrin (ISO);; reaction mass of rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl(1S,3S)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate and rel-(R)-cyano(4-fluoro-3-phenoxyphenyl)methyl(1S,3R)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate CAS 1820573-27-0
- bifenthrin (ISO); (2-methylbiphenyl-3-yl)methyl rel-(1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate CAS 82657-04-3
- bis(2-chloroethyl) ether CAS 111-44-4
- bis(2,4,6-trinitrophenyl)amine; hexyl CAS 131-73-7
- boron tribromide CAS 10294-33-4
- boron trichloride CAS 10294-34-5
- brodifacoum (ISO); 4-hydroxy-3-(3-(4'-bromo-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)coumarin CAS 56073-10-0
- bromadiolone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one CAS 28772-56-7
- brucine sulphate [1]; brucine nitrate [2]; Strychnidin-10-one, 2,3-dimethoxy-, mono[(R)-1-methylheptyl 1,2-benzenedicarboxylate] [3]; Strychnidin-10-one, 2,3-dimethoxy-, compd. with (S)mono(1-methylheptyl)-1,2-benzenedicarboxylate (1:1) [4] CAS 4845-99-2[1]5786-97-
- brucine; 2,3-dimethoxystrychnine CAS 357-57-3
- bufa-4,20,22-trienolide, 6-(acetyloxy)-3-(β-D-glucopyranosyloxy)-8,14-dihydroxy-, (3β, 6β)-; red squill; scilliroside CAS 507-60-8
- cadmium cyanide CAS 542-83-6
- calcium cyanide CAS 592-01-8
- calcium phosphide; tricalcium diphosphide CAS 1305-99-3
- carbofuran (ISO); 2,3-dihydro-2,2-dimethylbenzofuran-7-yl N-methylcarbamate CAS 1563-66-2
- chlorfenvinphos (ISO); 2-chloro-1-(2,4 dichlorophenyl) vinyl diethyl phosphate CAS 470-90-6
- chlormephos (ISO); S-chloromethyl O,O-diethyl phosphorodithioate CAS 24934-91-6
- chloronitroanilines with the exception of those specified elsewhere in this Annex Index No 610-006-00-0
- chlorophacinone (ISO); 2-[(4-chlorophenyl)(phenyl)acetyl]-1H-indene-1,3(2H)-dione CAS 3691-35-8
- chlorthiophos (ISO); [isomeric reaction mass in which O-2,5-dichlorophenyl-4-methylthiophenyl O,O-diethyl phosphorothioate predominates] CAS 21923-23-9
- colchicine CAS 64-86-8
- colecalciferol;; cholecalciferol;; Vitamin D3 CAS 67-97-0
- coumaphos (ISO); O-3-chloro-4-methylcoumarin-7-yl O,O-diethyl phosphorothioate CAS 56-72-4
- coumatetralyl (ISO); 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin CAS 5836-29-3
- crimidine (ISO); 2-chloro-6-methylpyrimidin-4-yldimethylamine CAS 535-89-7
- cyanthoate (ISO); S-(N-(1-cyano-1-methylethyl)carbamoylmethyl) O,O-diethyl phosphorothioate CAS 3734-95-0
- cycloheximide (ISO); 4-{}{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}}piperidine-2,6-dione CAS 66-81-9
- cyfluthrin (ISO); α-cyano-4-fluoro-3-phenoxybenzyl-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate CAS 68359-37-5
- demephion-O (ISO); O,O-dimethyl O-2-methylthioethyl phosphorothioate CAS 682-80-4
- demephion-S (ISO); O,O-dimethyl S-2-methylthioethyl phosphorothioate CAS 2587-90-8
- demeton CAS 8065-48-3
- demeton-O (ISO); O,O-diethyl-O-2-ethylthioethyl phosphorothioate CAS 298-03-3
- demeton-S (ISO); diethyl-S-2-ethylthioethyl phosphorothioate CAS 126-75-0
- dialifos (ISO); 2-chloro-1-phthalimidoethyl O,O-diethyl phosphorodithioate CAS 10311-84-9
- diarsenic trioxide; arsenic trioxide CAS 1327-53-3
- dicrotophos (ISO); (Z)-2-dimethylcarbamoyl-1-methylvinyl dimethyl phosphate CAS 141-66-2
- difenacoum (ISO); 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin CAS 56073-07-5
- difethialone (ISO);; 3-[3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one CAS 104653-34-1
- dimefox (ISO); tetramethylphosphorodiamidic fluoride CAS 115-26-4
- dimethyl 4-(methylthio)phenyl phosphate CAS 3254-63-5
- dimethylmercury [1]; diethylmercury [2] CAS 593-74-8[1]627-44-1[
- dinitrobenzene [1]; 1,4-dinitrobenzene [2]; 1,3-dinitrobenzene [3]; 1,2-dinitrobenzene [4] CAS 25154-54-5[1]100-25-
- dinoterb (ISO); 2-tert-butyl-4,6-dinitrophenol CAS 1420-07-1
- dioxathion (ISO); 1,4-dioxan-2,3-diyl-O,O,O',O'-tetraethyl di(phosphorodithioate) CAS 78-34-2
- diphacinone (ISO); 2-diphenylacetylindan-1,3-dione CAS 82-66-6
- dipicrylamine, ammonium salt CAS 2844-92-0
- disulfoton (ISO); O,O-diethyl 2-ethylthioethyl phosphorodithioate CAS 298-04-4
- dithallium sulphate; thallic sulphate CAS 7446-18-6
- DNOC (ISO); 4,6-dinitro-o-cresol CAS 534-52-1
- endosulfan (ISO); 1,2,3,4,7,7-hexachloro-8,9,10-trinorborn-2-en-5,6-ylenedimethylene sulfite; 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-en-2,3-ylenedimethylene sulfite CAS 115-29-7
- endrin (ISO); 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4:5,8-dimethanonaphthalene CAS 72-20-8
- ethyl bromoacetate CAS 105-36-2
- ethylene dinitrate; ethylene glycol dinitrate CAS 628-96-6
- ethyleneimine; aziridine CAS 151-56-4
- fenamiphos (ISO); ethyl-4-methylthio-m-tolyl isopropyl phosphoramidate CAS 22224-92-6
- fensulfothion (ISO); O,O-diethyl O-4-methylsulfinylphenyl phosphorothioate CAS 115-90-2
- flocoumafen (ISO); reaction mass of: cis-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin and trans-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin CAS 90035-08-8
- fluenetil (ISO); 2-fluoroethyl biphenyl-4-ylacetate CAS 4301-50-2
- fluoroacetates, soluble Index No 607-082-00-2
- fluoroacetic acid CAS 144-49-0
- fonofos (ISO); O-ethyl phenyl ethylphosphonodithioate CAS 944-22-9
- formetanate (ISO); 3-[(EZ)-dimethylaminomethyleneamino]phenyl methylcarbamate CAS 22259-30-9
- formetanate hydrochloride; 3-(N,N-dimethylaminomethyleneamino)phenyl N-methylcarbamate CAS 23422-53-9
- fosthietan (ISO); diethyl 1,3-dithietan-2-ylidenephosphoramidate CAS 21548-32-3
- glycerol trinitrate; nitroglycerine CAS 55-63-0
- hydrofluoric acid CAS 7664-39-3
- hyoscine CAS 51-34-3
- hyoscyamine CAS 101-31-5
- inorganic compounds of mercury with the exception of mercuric sulphide and those specified elsewhere in this Annex Index No 080-002-00-6
- isobenzan (ISO); 1,3,4,5,6,7,8,8-octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran CAS 297-78-9
- isodrin; (1α,4α,4aβ,5β,8β,8aβ)-1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene CAS 465-73-6
- lead alkyls Index No 082-002-00-1
- magnesium phosphide; trimagnesium diphosphide CAS 12057-74-8
- mephosfolan (ISO); diethyl 4-methyl-1,3-dithiolan-2-ylidenephosphoramidate CAS 950-10-7
- mercury dichloride; mercuric chloride CAS 7487-94-7
- methamidophos (ISO); O,S-dimethyl phosphoramidothioate CAS 10265-92-6
- methidathion (ISO); 2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl-O,O-dimethylphosphorodithioate CAS 950-37-8
- methomyl (ISO); 1-(methylthio)ethylideneamino N-methylcarbamate CAS 16752-77-5
- methylmercuric chloride CAS 115-09-3
- mevinphos (ISO); 2-methoxycarbonyl-1-methylvinyl dimethyl phosphate CAS 7786-34-7
- mexacarbate (ISO); 3,5-dimethyl-4-dimethylaminophenyl N-methylcarbamate CAS 315-18-4
- monocrotophos (ISO); dimethyl-1-methyl-2-(methylcarbamoyl)vinyl phosphate CAS 6923-22-4
- nicotine (ISO);; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine CAS 54-11-5
- O-ethyl O-4-nitrophenyl phenylphosphonothioate; EPN CAS 2104-64-5
- organic compounds of mercury with the exception of those specified elsewhere in this Annex Index No 080-004-00-7
- osmium tetraoxide; osmic acid CAS 20816-12-0
- oxamyl (ISO); N',N'-dimethylcarbamoyl(methylthio)methylenamine N-methylcarbamate CAS 23135-22-0
- oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate CAS 693-21-0
- oxydisulfoton (ISO); O, O-diethyl S-2-ethylsulphinylethyl phosphorodithioate CAS 2497-07-6
- p-anisidine; 4-methoxyaniline CAS 104-94-9
- parathion - methyl (ISO); O,O-dimethyl O-4-nitrophenyl phosphorothioate CAS 298-00-0
- parathion (ISO); O,O-diethyl O-4-nitrophenyl phosphorothioate CAS 56-38-2
- phorate (ISO); O,O-diethyl ethylthiomethyl phosphorodithioate CAS 298-02-2
- phosacetim (ISO); O,O-bis(4-chlorophenyl) N-acetimidoylphosphoramidothioate CAS 4104-14-7
- phosfolan (ISO); diethyl 1,3-dithiolan-2-ylidenephosphoramidate CAS 947-02-4
- phosphamidon (ISO); 2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate CAS 13171-21-6
- phosphorus trichloride CAS 7719-12-2
- physostigmine CAS 57-47-6
- pilocarpine CAS 92-13-7
- potasan; O,O-diethyl O-(4-methylcoumarin-7-yl) phosphorothioate CAS 299-45-6
- prothoate (ISO); O,O-diethyl isopropylcarbamoylmethyl phosphorodithioate CAS 2275-18-5
- pyrazoxon; diethyl 3-methylpyrazol-5-yl phosphate CAS 108-34-9
- S-[2-(ethylsulphinyl)ethyl] O,O-dimethyl phosphorodithioate CAS 2703-37-9
- salts and esters of dinoterb Index No 609-031-00-X
- salts of aconitine Index No 614-009-00-8
- salts of atropine Index No 614-011-00-9
- salts of hyoscine Index No 614-015-00-0
- salts of hyoscyamine Index No 614-013-00-X
- salts of nicotine Index No 614-002-00-X
- salts of physostigmine Index No 614-021-00-3
- salts of pilocarpine Index No 614-017-00-1
- salts of strychnine Index No 614-004-00-0
- schradan (ISO); octamethylpyrophosphoramide CAS 152-16-9
- sodium azide CAS 26628-22-8
- sodium fluoroacetate CAS 62-74-8
- sodium selenite CAS 10102-18-8
- strychnine CAS 57-24-9
- sulfotep (ISO); O,O,O,O-tetraethyl dithiopyrophosphate CAS 3689-24-5
- tefluthrin (ISO);; 2,3,5,6-tetrafluoro-4-methylbenzyl (1RS,3RS)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylate CAS 79538-32-2
- TEPP (ISO); tetraethyl pyrophosphate CAS 107-49-3
- terbufos (ISO); S-tert-butylthiomethyl O,O-diethylphosphorodithioate CAS 13071-79-9
- thallium CAS 7440-28-0
- thallium compounds, with the exception of those specified elsewhere in this Annex Index No 081-002-00-9
- thallium thiocyanate CAS 3535-84-0
- thiofanox (ISO); 3,3-dimethyl-1-(methylthio)butanone-O-(N-methylcarbamoyl)oxime CAS 39196-18-4
- thionazin (ISO); O,O-diethyl O-pyrazin-2-yl phosphorothioate CAS 297-97-2
- triamiphos (ISO); 5-amino-3-phenyl-1,2,4-triazol-1-yl-N,N,N',N'-tetramethylphosphonic diamide CAS 1031-47-6
- trichloronate (ISO); O-ethyl O-2,4,5-trichlorophenyl ethylphosphonothioate CAS 327-98-0
- triethyltin compounds, with the exception of those specified elsewhere in this Annex Index No 050-006-00-2
- trimethyltin compounds, with the exception of those specified elsewhere in this Annex Index No 050-005-00-7
- trizinc diphosphide; zinc phosphide CAS 1314-84-7
- uranium CAS 7440-61-1
- warfarin (ISO); 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one [1]; (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone [2]; (R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone [3] CAS 81-81-2[1]5543-57-7[
- white phosphorus CAS 12185-10-3
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Wording quoted from the regulation named above. Substance counts come from harmonised classifications in CLP Annex VI — the statements on a real product also depend on the supplier's own classification. Always check the supplier safety data sheet.