Substance profile
Prothoate
Prothoate is colorless yellow crystals (tech is an amber to yellow semi-solid) with a camphor-like odor.
01 · Identification
What Prothoate is
Prothoate is colorless yellow crystals (tech is an amber to yellow semi-solid) with a camphor-like odor. Its molecular formula is C9H20NO3PS2 and its molecular weight is 285.4 g/mol. It boils at 330 °C, melts at 28.5 °C.
Under the GHS it carries the signal word Danger.
Other names for Prothoate
- prothoate (ISO)
- O,O-diethyl isopropylcarbamoylmethyl phosphorodithioate
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H310 | Fatal in contact with skin. |
| H300 | Fatal if swallowed. |
| H412 | Harmful to aquatic life with long lasting effects. |
Precautionary statements: P270, P273, P280, P301, P302, P310, P330, P352, P501
03 · Physical and chemical properties
Prothoate properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 330 °C (626 °F) | at 760 mmHg | DOE PAC |
| Melting point | 28.5 °C (83.3 °F) | HSDB | |
| Density | 1.151 g/cm³ | at 32 °C | HSDB |
| Solubility | Miscible with most organic solvents e.g. hexane, cyclohexane, higher petroleum fractions <30. Light petroleum <20, glycerol <10 (all in g/kg , 20 °C) | at 20 °C | HSDB |
| In water, 2.5X10+3 mg/L at 20 °C | at 20 °C | HSDB | |
| Vapor pressure | 0.0001 mmHg | at 25 °C | DOE PAC |
| 0.0000975 mmHg | at 40 °C | HSDB | |
| 0.0001 mmHg | at 40 °C | CAMEO |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Source notes
Further notes on Prothoate
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
SOLIDIFIES AT 21 TO 24 °C; AMBER TO YELLOW SEMI-SOLID; MISCIBLE AT 20 °C WITH MOST ORGANIC SOLVENTS; SOLUBILITY LESS THAN: 10 G/KG GLYCEROL, 20 G/KG LIGHT PETROLEUM, 30 G/KG CYCLOHEXANE, HEXANE & HIGHER PETROLEUM FRACTIONS /TECHNICAL PRODUCT/
Source: HSDB
05 · Handling and storage
Storing and handling Prothoate
Storage conditions
Storage: Prior to working with this chemical you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, well-ventilated area. Where possible, automatically transfer material from drums or other storage containers to process containers. Sources of ignition such as smoking and open flames are prohibited where this chemical is handled, used, or stored. Metal containers involving the transfer of this chemical should be grounded and bonded. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
Organothiophosphates, such as PROTHOATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Prothoate in the storage compatibility matrix →