Health hazard · Acute toxicity - dermal
H310 — Fatal in contact with skin
Health hazard statements describe what the substance does to a person exposed to it. 83 substances with a harmonised EU classification carry this code.
01 · Wording
What H310 says
Fatal in contact with skin.
CLP Annex III · Health hazards
Acute toxicity - dermal GHS chapter 3.1
Category 2, 1 · pictogram GHS06 (skull and crossbones) · signal word Danger
Unchanged since 2009.
Present in every UN GHS edition from Rev.3 (2009) to Rev.11 (2025), with the same wording throughout.
Nine editions of the UN model text, 86 hazard statements, 19 of which ever moved. Read the full story in what changed in UN GHS Rev.11.
02 · Legal status
Where H310 is current
GHS is a United Nations model text, revised every two years, and each jurisdiction adopts a revision on its own timetable. A code can be legally current in one system and deleted in another — that is normal, not an error.
| Jurisdiction | Basis | Status of H310 |
|---|---|---|
| EU CLP | Regulation (EC) 1272/2008 CLP Annex IV, Part 2 (consolidated) | Current |
| US OSHA HazCom | 29 CFR 1910.1200 Appendix C UN GHS Rev.7 (final rule of 20 May 2024) | Current |
| US HazCom 2012 | legacy · GHS Rev.3 UN GHS Rev.3, Annex 3 | Current |
| UN GHS | Rev.11 (2025) UN GHS Rev.11, Annex 3 | Current |
Currently in force under: EU CLP, US OSHA HazCom, US HazCom 2012, UN GHS. Sources: EU CLP · US OSHA HazCom · US HazCom 2012 · UN GHS
03 · On a label
H310 also appears combined
CLP Annex III defines combined hazard statements as single label elements. H310 is a component of 3 of them — this is how you will actually see it printed. The combinations have no pages of their own: a plus sign in a URL has to be encoded and breaks in other people's links and in analytics.
| Code | Combined statement |
|---|---|
| H300+H310 | Fatal if swallowed or in contact with skin. CLP verbatim: Fatal if swallowed or in contact with skin |
| H310+H330 | Fatal in contact with skin or if inhaled. CLP verbatim: Fatal in contact with skin or if inhaled |
| H300+H310+H330 | Fatal if swallowed, in contact with skin or if inhaled. CLP verbatim: Fatal if swallowed, in contact with skin or if inhaled |
04 · Substances
Substances carrying H310
Every entry whose harmonised CLP Annex VI classification includes this hazard statement. Substances with a reference page here open on this site; the rest open on ghssymbols.com. Of these, 8 are group entries such as “salts of picric acid” or “beryllium compounds” — Annex VI gives them no CAS number, so they are listed by Index No and have no page of their own.
- 1-isopropyl-3-methylpyrazol-5-yl dimethylcarbamate; Isolan CAS 119-38-0
- 1,1,2,2-tetrachloroethane CAS 79-34-5
- 1,3,5-trinitrobenzene CAS 99-35-4
- 2-chloro-1,3,5-trinitrobenzene CAS 88-88-0
- 2-chloroethanol; ethylene chlorohydrin CAS 107-07-3
- 2-hydroxy-2-methylpropionitrile; 2-cyanopropan-2-ol; acetone cyanohydrin CAS 75-86-5
- 2-methylaziridine; propyleneimine CAS 75-55-8
- 2-nitro-p-anisidine; 4-methoxy-2-nitroaniline CAS 96-96-8
- 2,4-dinitroaniline CAS 97-02-9
- ammonium salt of DNOC; ammonium 4,6-dinitro-o-tolyl oxide CAS 2980-64-5
- bis(2-chloroethyl) ether CAS 111-44-4
- bis(2,4,6-trinitrophenyl)amine; hexyl CAS 131-73-7
- brodifacoum (ISO); 4-hydroxy-3-(3-(4'-bromo-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)coumarin CAS 56073-10-0
- bromadiolone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one CAS 28772-56-7
- cadmium cyanide CAS 542-83-6
- chlormephos (ISO); S-chloromethyl O,O-diethyl phosphorodithioate CAS 24934-91-6
- chloronitroanilines with the exception of those specified elsewhere in this Annex Index No 610-006-00-0
- chlorophacinone (ISO); 2-[(4-chlorophenyl)(phenyl)acetyl]-1H-indene-1,3(2H)-dione CAS 3691-35-8
- colecalciferol;; cholecalciferol;; Vitamin D3 CAS 67-97-0
- demeton CAS 8065-48-3
- demeton-O (ISO); O,O-diethyl-O-2-ethylthioethyl phosphorothioate CAS 298-03-3
- demeton-S (ISO); diethyl-S-2-ethylthioethyl phosphorothioate CAS 126-75-0
- dieldrin (ISO) CAS 60-57-1
- difenacoum (ISO); 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin CAS 56073-07-5
- difethialone (ISO);; 3-[3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one CAS 104653-34-1
- dimefox (ISO); tetramethylphosphorodiamidic fluoride CAS 115-26-4
- dimethyl 4-(methylthio)phenyl phosphate CAS 3254-63-5
- dimethylmercury [1]; diethylmercury [2] CAS 593-74-8[1]627-44-1[
- dinitrobenzene [1]; 1,4-dinitrobenzene [2]; 1,3-dinitrobenzene [3]; 1,2-dinitrobenzene [4] CAS 25154-54-5[1]100-25-
- dipicrylamine, ammonium salt CAS 2844-92-0
- disulfoton (ISO); O,O-diethyl 2-ethylthioethyl phosphorodithioate CAS 298-04-4
- DNOC (ISO); 4,6-dinitro-o-cresol CAS 534-52-1
- ethoprophos (ISO); ethyl-S,S-dipropyl phosphorodithioate CAS 13194-48-4
- ethyl bromoacetate CAS 105-36-2
- ethylene dinitrate; ethylene glycol dinitrate CAS 628-96-6
- ethyleneimine; aziridine CAS 151-56-4
- fenamiphos (ISO); ethyl-4-methylthio-m-tolyl isopropyl phosphoramidate CAS 22224-92-6
- fensulfothion (ISO); O,O-diethyl O-4-methylsulfinylphenyl phosphorothioate CAS 115-90-2
- flocoumafen (ISO); reaction mass of: cis-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin and trans-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin CAS 90035-08-8
- fluenetil (ISO); 2-fluoroethyl biphenyl-4-ylacetate CAS 4301-50-2
- fonofos (ISO); O-ethyl phenyl ethylphosphonodithioate CAS 944-22-9
- fosthietan (ISO); diethyl 1,3-dithietan-2-ylidenephosphoramidate CAS 21548-32-3
- glycerol trinitrate; nitroglycerine CAS 55-63-0
- hydrofluoric acid CAS 7664-39-3
- hyoscine CAS 51-34-3
- inorganic compounds of mercury with the exception of mercuric sulphide and those specified elsewhere in this Annex Index No 080-002-00-6
- IPSP; S-ethylsulphinylmethyl O,O-diisopropylphosphorodithioate CAS 5827-05-4
- isobenzan (ISO); 1,3,4,5,6,7,8,8-octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran CAS 297-78-9
- isodrin; (1α,4α,4aβ,5β,8β,8aβ)-1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene CAS 465-73-6
- lead alkyls Index No 082-002-00-1
- mephosfolan (ISO); diethyl 4-methyl-1,3-dithiolan-2-ylidenephosphoramidate CAS 950-10-7
- methylmercuric chloride CAS 115-09-3
- mevinphos (ISO); 2-methoxycarbonyl-1-methylvinyl dimethyl phosphate CAS 7786-34-7
- nicotine (ISO);; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine CAS 54-11-5
- O-ethyl O-4-nitrophenyl phenylphosphonothioate; EPN CAS 2104-64-5
- organic compounds of mercury with the exception of those specified elsewhere in this Annex Index No 080-004-00-7
- osmium tetraoxide; osmic acid CAS 20816-12-0
- oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate CAS 693-21-0
- p-anisidine; 4-methoxyaniline CAS 104-94-9
- peracetic acid . . . % CAS 79-21-0
- phorate (ISO); O,O-diethyl ethylthiomethyl phosphorodithioate CAS 298-02-2
- phosacetim (ISO); O,O-bis(4-chlorophenyl) N-acetimidoylphosphoramidothioate CAS 4104-14-7
- phosfolan (ISO); diethyl 1,3-dithiolan-2-ylidenephosphoramidate CAS 947-02-4
- potasan; O,O-diethyl O-(4-methylcoumarin-7-yl) phosphorothioate CAS 299-45-6
- prothoate (ISO); O,O-diethyl isopropylcarbamoylmethyl phosphorodithioate CAS 2275-18-5
- pyrazoxon; diethyl 3-methylpyrazol-5-yl phosphate CAS 108-34-9
- reaction mass of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1) CAS 55965-84-9
- S-[2-(ethylsulphinyl)ethyl] O,O-dimethyl phosphorodithioate CAS 2703-37-9
- salts of hyoscine Index No 614-015-00-0
- salts of nicotine Index No 614-002-00-X
- schradan (ISO); octamethylpyrophosphoramide CAS 152-16-9
- sodium fluoroacetate CAS 62-74-8
- strychnine CAS 57-24-9
- sulfotep (ISO); O,O,O,O-tetraethyl dithiopyrophosphate CAS 3689-24-5
- tefluthrin (ISO);; 2,3,5,6-tetrafluoro-4-methylbenzyl (1RS,3RS)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylate CAS 79538-32-2
- TEPP (ISO); tetraethyl pyrophosphate CAS 107-49-3
- terbufos (ISO); S-tert-butylthiomethyl O,O-diethylphosphorodithioate CAS 13071-79-9
- thiofanox (ISO); 3,3-dimethyl-1-(methylthio)butanone-O-(N-methylcarbamoyl)oxime CAS 39196-18-4
- thionazin (ISO); O,O-diethyl O-pyrazin-2-yl phosphorothioate CAS 297-97-2
- triamiphos (ISO); 5-amino-3-phenyl-1,2,4-triazol-1-yl-N,N,N',N'-tetramethylphosphonic diamide CAS 1031-47-6
- triethyltin compounds, with the exception of those specified elsewhere in this Annex Index No 050-006-00-2
- trimethyltin compounds, with the exception of those specified elsewhere in this Annex Index No 050-005-00-7
- warfarin (ISO); 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one [1]; (S)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone [2]; (R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone [3] CAS 81-81-2[1]5543-57-7[
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All hazard statements
The full list of H-codes with the jurisdiction switch lives on the hazard statements hub. For what to do about the hazard, see precautionary statements (P-codes).
Wording quoted from the regulation named above. Substance counts come from harmonised classifications in CLP Annex VI — the statements on a real product also depend on the supplier's own classification. Always check the supplier safety data sheet.