Health hazard · Germ cell mutagenicity
H341 — Suspected of causing genetic defects
Health hazard statements describe what the substance does to a person exposed to it. 153 substances with a harmonised EU classification carry this code.
EU CLP: currentUS OSHA HazCom: currentUS HazCom 2012: currentUN GHS: current
01 · Wording
What H341 says
Official
Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. The wording is incomplete on purpose. The route of exposure — stated only where it is conclusively proven that no other route of exposure causes the hazard.
Typical
Suspected of causing genetic defects. How it usually reads on a label and on a safety data sheet. We show it separately rather than presenting a filled-in blank as the regulation's own text.
Source
CLP Annex III · Health hazards
Classification 
Germ cell mutagenicity GHS chapter 3.5
Category 2 · pictogram GHS08 (health hazard) · signal word Warning
Reading the official wording. <angle brackets> mark a blank the supplier fills in — not a truncated sentence.· UN GHS prints the same blanks in round brackets, CLP in angle ones.· P-codes use a different notation — an ellipsis and square brackets.
UN GHS history
Unchanged since 2009.
Rev.3 2009
Rev.4 2011
Rev.5 2013
Rev.6 2015
Rev.7 2017
Rev.8 2019
Rev.9 2021
Rev.10 2023
Rev.11 2025
wording never changed
Present in every UN GHS edition from Rev.3 (2009) to Rev.11 (2025), with the same wording throughout.
Nine editions of the UN model text, 86 hazard statements, 19 of which ever moved. Read the full story in what changed in UN GHS Rev.11.
02 · Legal status
Where H341 is current
GHS is a United Nations model text, revised every two years, and each jurisdiction adopts a revision on its own timetable. A code can be legally current in one system and deleted in another — that is normal, not an error.
| Jurisdiction | Basis | Status of H341 |
|---|---|---|
| EU CLP | Regulation (EC) 1272/2008 CLP Annex IV, Part 2 (consolidated) | Current |
| US OSHA HazCom | 29 CFR 1910.1200 Appendix C UN GHS Rev.7 (final rule of 20 May 2024) | Current |
| US HazCom 2012 | legacy · GHS Rev.3 UN GHS Rev.3, Annex 3 | Current |
| UN GHS | Rev.11 (2025) UN GHS Rev.11, Annex 3 | Current |
Currently in force under: EU CLP, US OSHA HazCom, US HazCom 2012, UN GHS. Sources: EU CLP · US OSHA HazCom · US HazCom 2012 · UN GHS
03 · Substances
Substances carrying H341
Every entry whose harmonised CLP Annex VI classification includes this hazard statement. Substances with a reference page here open on this site; the rest open on ghssymbols.com. Of these, 8 are group entries such as “salts of picric acid” or “beryllium compounds” — Annex VI gives them no CAS number, so they are listed by Index No and have no page of their own.
- (3-chlorophenyl)-(4-methoxy-3-nitrophenyl)methanone CAS 66938-41-8
- (4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride CAS 81880-96-8
- (6R-trans)-1-((7-ammonio-2-carboxylato-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-yl)methyl)pyridinium iodide CAS 100988-63-4
- [(p-tolyloxy)methyl]oxirane [1]; [(m-tolyloxy)methyl]oxirane [2]; 2,3-epoxypropyl o-tolyl ether [3]; [(tolyloxy)methyl]oxirane; cresyl glycidyl ether [4] CAS 2186-24-5[1]2186-25-
- 1-(1-naphthylmethyl)quinolinium chloride CAS 65322-65-8
- 1-chloro-4-nitrobenzene CAS 100-00-5
- 1-ethyl-1-methylmorpholinium bromide CAS 65756-41-4
- 1-ethyl-1-methylpyrrolidinium bromide CAS 69227-51-6
- 1,2-dihydroxybenzene;; pyrocatechol CAS 120-80-9
- 1,3-Bis(vinylsulfonylacetamido)propane CAS 93629-90-4
- 1,4-dihydroxybenzene; hydroquinone; quinol CAS 123-31-9
- 2-(isocyanatosulfonylmethyl)benzoic acid methyl ester; (alt.):methyl 2-(isocyanatosulfonylmethyl)benzoate CAS 83056-32-0
- 2-aminophenol CAS 95-55-6
- 2-methoxyaniline; o-anisidine CAS 90-04-0
- 2-methoxyethyl acrylate CAS 3121-61-7
- 2-methyl-m-phenylenediamine; 2,6-toluenediamine CAS 823-40-5
- 2,2-dimethylpropan-1-ol, tribromo derivative; 3-bromo-2,2-bis(bromomethyl)propan-1-ol CAS 36483-57-5
- 2,3-dichloropropene; 2,3-dichloropropylene CAS 78-88-6
- 2,3-dinitrotoluene CAS 602-01-7
- 2,3-epoxypropan-1-ol; glycidol; oxiranemethanol CAS 556-52-5
- 2,3-epoxypropyl methacrylate; glycidyl methacrylate CAS 106-91-2
- 2,3-epoxypropyl neodecanoate CAS 26761-45-5
- 2,3-epoxypropyltrimethylammonium chloride ...%; glycidyl trimethylammonium chloride ...% CAS 3033-77-0
- 2,4-diaminoanisole; 4-methoxy-m-phenylenediamine [1]; 2,4-diaminoanisole sulphate [2] CAS 615-05-4[1]39156-41-
- 2,4-dinitrotoluene [1]; dinitrotoluene [2] CAS 121-14-2[1]25321-14-
- 2,5-dinitrotoluene CAS 619-15-8
- 2,6-dinitrotoluene CAS 606-20-2
- 3-chloro-4-(3-fluorobenzyloxy)aniline CAS 202197-26-0
- 3-chloropropene; allyl chloride CAS 107-05-1
- 3,4-dinitrotoluene CAS 610-39-9
- 3,5-dinitrotoluene CAS 618-85-9
- 4-aminophenol CAS 123-30-8
- 4-chloro-o-toluidine [1]; 4-chloro-o-toluidine hydrochloride [2] CAS 95-69-2[1]3165-93-3[
- 4-ethoxyaniline; p-phenetidine CAS 156-43-4
- 4-methyl-m-phenylenediamine; 2,4-toluenediamine CAS 95-80-7
- 4-nitrosomorpholine CAS 59-89-2
- 4-nitrosophenol CAS 104-91-6
- 4,4'-bis(dimethylamino)benzophenone; Michler's ketone CAS 90-94-8
- 4,4'-diaminodiphenylmethane; 4,4'-methylenedianiline CAS 101-77-9
- 4'-ethoxy-2-benzimidazoleanilide CAS 120187-29-3
- 5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine)-3-fluoro-2-hydroxymethyltetrahydrofuran CAS 41107-56-6
- 6-glycidyloxynapht-1-yl oxymethyloxirane CAS 27610-48-6
- 7-oxa-3-oxiranylbicyclo [4.1.0]heptane; 1,2-epoxy- 4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide CAS 106-87-6
- 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate CAS 2386-87-0
- 9-vinylcarbazole CAS 1484-13-5
- acetaldehyde;; ethanal CAS 75-07-0
- allyl glycidyl ether; allyl 2,3-epoxypropyl ether; prop-2-en-1-yl 2,3-epoxypropyl ether CAS 106-92-3
- aniline CAS 62-53-3
- azobenzene CAS 103-33-3
- benzo[rst]pentaphene CAS 189-55-9
- biphenyl-3,3',4,4'-tetrayltetraamine; diaminobenzidine CAS 91-95-2
- bromomethane; methylbromide CAS 74-83-9
- butyl glycidyl ether; butyl 2,3-epoxypropyl ether CAS 2426-08-6
- C.I. Solvent Yellow 14; 1-phenylazo-2-naphthol CAS 842-07-9
- cadmium CAS 7440-43-9
- cadmium (non-pyrophoric) [1]; cadmium oxide (non-pyrophoric) [2] CAS 7440-43-9[1]1306-19-
- cadmium sulphide CAS 1306-23-6
- chloro-1-ethylcyclohexyl carbonate CAS 99464-83-2
- chrysene CAS 218-01-9
- chrysoidine C10-14-alkyl derivatives; benzenesulfonic acid, mono-C10-14-alkyl derivatives, compounds with 4-(phenylazo)-1,3-benzenediamine [1]; chrysoidine compound with dibutylnaphthalene sulfonic acid; dibutylnaphthalenesulfonic acid, compound with 4-(phenylazo)benzene-1,3-diamine (1:1) [2] CAS 85407-90-5[1]94247-6
- chrysoidine monohydrochloride; 4-phenylazophenylene-1,3-diamine monohydrochloride [1]; chrysoidine monoacetate; 4-(phenylazo)benzene-1,3-diamine monoacetate [2]; chrysoidine acetate; 4-(phenylazo)benzene-1,3-diamine acetate [3]; chrysoidine-p-dodecylbenzenesulfonate; dodecylbenzenesulfonic acid, compound with 4-(phenylazo)benzene-1,3-diamine (1:1) [4]; chrysoidine dihydrochloride; 4-(phenylazo)benzene-1,3-diamine dihydrochloride [5]; chrysoidine sulfate; bis[4-(phenylazo)benzene-1,3-diamine] sulfate [6] CAS 532-82-1[1]75660-25-
- chrysoidine; 4-(phenylazo)benzene-1,3-diamine CAS 495-54-5
- cobalt CAS 7440-48-4
- cobalt carbonate CAS 513-79-1
- cobalt di(acetate) CAS 71-48-7
- cobalt dichloride CAS 7646-79-9
- cobalt dinitrate CAS 10141-05-6
- cobalt sulfate CAS 10124-43-3
- crotonaldehyde; 2-butenal [1]; (E)-2-butenal; (E)-crotonaldehyde [2] CAS 4170-30-3[1]123-73-9
- cycloheximide (ISO); 4-{}{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}}piperidine-2,6-dione CAS 66-81-9
- di-tert-butyl peroxide CAS 110-05-4
- dibenzo[b,def]chrysene;; dibenzo[a,h]pyrene CAS 189-64-0
- dibenzo[def,p]chrysene; dibenzo[a,l]pyrene CAS 191-30-0
- dibutyltin bis; (2-ethylhexanoate) CAS 2781-10-4
- dibutyltin di(acetate) CAS 1067-33-0
- dibutyltin dichloride; (DBTC) CAS 683-18-1
- dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)]stannane CAS 77-58-7
- dibutyltin hydrogen borate CAS 75113-37-0
- dibutyltin maleate CAS 78-04-6
- dibutyltin oxide CAS 818-08-6
- dimethyl sulphate CAS 77-78-1
- divanadium pentaoxide; vanadium pentoxide CAS 1314-62-1
- DNOC (ISO); 4,6-dinitro-o-cresol CAS 534-52-1
- ethidium bromide; 3,8-diamino-1-ethyl-6-phenylphenantridinium bromide CAS 1239-45-8
- fenthion (ISO); O,O-dimethyl-O-(4-methylthion-m-tolyl) phosphorothioate CAS 55-38-9
- formaldehyde CAS 50-00-0
- furan CAS 110-00-9
- glyoxal … %; ethandial … % CAS 107-22-2
- hexahydrocyclopenta[c]pyrrole-1-(1H)-ammonium N-ethoxycarbonyl-N-(p-tolylsulfonyl)azanide Index No 016-081-00-0
- isobutyl nitrite CAS 542-56-3
- isoprene (stabilised); 2-methyl-1,3-butadiene CAS 78-79-5
- leucomalachite green; N,N,N',N'-tetramethyl-4,4'-benzylidenedianiline CAS 129-73-7
- m-bis(2,3-epoxypropoxy)benzene; resorcinol diglycidyl ether CAS 101-90-6
- m-phenylenediamine CAS 108-45-2
- m-phenylenediamine dihydrochloride CAS 541-69-5
- mercury dichloride; mercuric chloride CAS 7487-94-7
- monocrotophos (ISO); dimethyl-1-methyl-2-(methylcarbamoyl)vinyl phosphate CAS 6923-22-4
- N,N,N',N'-tetraglycidyl-4,4'-diamino-3,3'-diethyldiphenylmethane CAS 130728-76-6
- N,N'-diacetylbenzidine CAS 613-35-4
- N,N',N''-tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6-oxo-1,3,5-triazine CAS 26157-73-3
- N,N′-methylenedimorpholine;; N,N′-methylenebismorpholine;; [formaldehyde released from N,N′-methylenebismorpholine];; [MBM] CAS 5625-90-1
- nickel (II) sulfide [1]; nickel sulfide [2]; millerite [3] CAS 16812-54-7[1]11113-7
- nickel bis(4-cyclohexylbutyrate) CAS 3906-55-6
- nickel bis(sulfamidate);; nickel sulfamate CAS 13770-89-3
- nickel bis(tetrafluoroborate) CAS 14708-14-6
- nickel carbonate; basic nickel carbonate; carbonic acid, nickel (2+) salt [1]; carbonic acid, nickel salt [2]; [µ-[carbonato(2-)-O:O’]] dihydroxy trinickel [3]; [carbonato(2-)] tetrahydroxytrinickel [4] CAS 3333-67-3[1]16337-84
- nickel di(acetate) [1]; nickel acetate [2] CAS 373-02-4[1]14998-37-
- nickel dibenzoate CAS 553-71-9
- nickel dichlorate [1]; nickel dibromate [2]; ethyl hydrogen sulfate, nickel(II) salt [3] CAS 67952-43-6[1]14550-8
- nickel dichloride CAS 7718-54-9
- nickel dichromate CAS 15586-38-6
- nickel difluoride [1]; nickel dibromide [2]; nickel diiodide [3]; nickel potassium fluoride [4] CAS 10028-18-9[1]13462-8
- nickel diformate [1]; formic acid, nickel salt [2]; formic acid, copper nickel salt [3] CAS 3349-06-2[1]15843-02
- nickel dihydroxide [1]; nickel hydroxide [2] CAS 12054-48-7[1]11113-7
- nickel dilactate CAS 16039-61-5
- nickel dinitrate [1]; nitric acid, nickel salt [2] CAS 13138-45-9[1]14216-7
- nickel diperchlorate; perchloric acid, nickel(II) salt CAS 13637-71-3
- nickel dipotassium bis(sulfate) [1]; diammonium nickel bis(sulfate) [2] CAS 13842-46-1[1]15699-1
- nickel dithiocyanate CAS 13689-92-4
- nickel hexafluorosilicate CAS 26043-11-8
- nickel selenate CAS 15060-62-5
- nickel sulfate CAS 7786-81-4
- nickel(II) octanoate CAS 4995-91-9
- nickel(II) stearate; nickel(II) octadecanoate CAS 2223-95-2
- nickel(II) trifluoroacetate [1]; nickel(II) propionate [2]; nickel bis(benzenesulfonate) [3]; nickel(II) hydrogen citrate [4]; citric acid, ammonium nickel salt [5]; citric acid, nickel salt [6]; nickel bis(2-ethylhexanoate) [7]; 2-ethylhexanoic acid, nickel salt [8]; dimethylhexanoic acid nickel salt [9]; nickel(II) isooctanoate [10]; nickel isooctanoate [11]; nickel bis(isononanoate) [12]; nickel(II) neononanoate [13]; nickel(II) isodecanoate [14]; nickel(II) neodecanoate [15]; neodecanoic acid, nickel salt [16]; nickel(II) neoundecanoate [17]; bis(.sc.d.sc.-gluconato-O1,O2)nickel [18]; nickel 3,5-bis(tert-butyl)-4-hydroxybenzoate (1:2) [19]; nickel(II) palmitate [20]; (2-ethylhexanoato-O)(isononanoato-O)nickel [21]; (isononanoato-O)(isooctanoato-O)nickel [22]; (isooctanoato-O)(neodecanoato-O)nickel [23]; (2-ethylhexanoato-O)(isodecanoato-O)nickel [24]; (2-ethylhexanoato-O)(neodecanoato-O)nickel [25]; (isodecanoato-O)(isooctanoato-O)nickel [26]; (isodecanoato-O)(isononanoato-O)nickel [27]; (isononanoato-O)(neodecanoato-O)nickel [28]; fatty acids, C6-19-branched, nickel salts [29]; fatty acids, C8-18 and C18-unsaturated, nickel salts [30]; 2,7-naphthalenedisulfonic acid, nickel(II) salt [31] CAS 16083-14-0[1]3349-08
- o-phenylenediamine CAS 95-54-5
- o-phenylenediamine dihydrochloride CAS 615-28-1
- oxiranemethanol, 4-methylbenzene-sulfonate, (S)- CAS 70987-78-9
- phenol CAS 108-95-2
- phenolphthalein CAS 77-09-8
- phenyl glycidyl ether; 2,3-epoxypropyl phenyl ether; 1,2-epoxy-3-phenoxypropane CAS 122-60-1
- phenylhydrazine [1]; phenylhydrazinium chloride [2]; phenylhydrazine hydrochloride [3]; phenylhydrazinium sulphate (2:1) [4] CAS 100-63-0[1]59-88-1[2
- phosphamidon (ISO); 2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate CAS 13171-21-6
- pyrogallol; 1,2,3-trihydroxybenzene CAS 87-66-1
- quinoline CAS 91-22-5
- R-2,3-epoxy-1-propanol CAS 57044-25-4
- reaction mass of 1-(2,3-epoxypropoxy)–2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane Index No 603-244-00-1
- reaction mass of: 4-allyl-2,6-bis(2,3-epoxypropyl)phenol; 4-allyl-6-[3-[6-[3-[6-[3-(4-allyl-2,6-bis(2,3-epoxypropyl)phenoxy)-2-hydroxypropyl]-4-allyl-2-(2,3-epoxypropyl)phenoxy]-2-hydroxypropyl]-4-allyl-2-(2,3-epoxypropyl)phenoxy]-2-hydroxypropyl]-2-(2,3-epoxypropyl)phenol; 4-allyl-6-[3-(4-allyl-2,6-bis(2,3-epoxypropyl)phenoxy)-2-hydroxypropyl]-2-(2,3-epoxypropyl)phenol; 4-allyl-6-[3-[6-[3-(4-allyl-2,6-bis(2,3-epoxypropyl)phenoxy)-2-hydroxypropyl]-4-allyl-2-(2,3-epoxypropyl)phenoxy]-2-hydroxypropyl]-2-(2,3-epoxypropyl)phenol Index No 603-165-00-2
- reaction mass of: N-[3-hydroxy-2-(2-methylacryloylaminomethoxy)propoxymethyl]-2-methylacrylamide; N-[2,3-bis-(2-methylacryloylaminomethoxy)propoxymethyl]-2-methylacrylamide; methacrylamide; 2-methyl-N-(2-methylacryloylaminomethoxymethyl)-acrylamide; N-(2,3-dihydroxypropoxymethyl)-2-methylacrylamide Index No 616-057-00-5
- reaction products of paraformaldehyde and 2-hydroxypropylamine (ratio 3:2);; [formaldehyde released from 3,3′-methylenebis[5-methyloxazolidine];; [formaldehyde released from oxazolidin];; [MBO] Index No 612-290-00-1
- reaction products of paraformaldehyde with 2-hydroxypropylamine (ratio 1:1);; [formaldehyde released from α,α,α-trimethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-triethanol];; [HPT] Index No 612-291-00-7
- safrole; 5-allyl-1,3-benzodioxole CAS 94-59-7
- salts of aniline Index No 612-009-00-2
- slimes and sludges, copper electrolyte refining, decopperised CAS 94551-87-8
- slimes and sludges, copper electrolytic refining, decopperised, nickel sulfate CAS 92129-57-2
- sodium N-(hydroxymethyl)glycinate; [formaldehyde released from sodium N-(hydroxymethyl)glycinate] CAS 70161-44-3
- tert-butyl hydroperoxide CAS 75-91-2
- thiophanate-methyl (ISO);; dimethyl (1,2-phenylenedicarbamo-thioyl)biscarbamate; dimethyl 4,4′-(o-phenylene) bis(3-thioallophanate) CAS 23564-05-8
- trichloroethylene CAS 79-01-6
- trifluoroiodomethane; trifluoromethyl iodide CAS 2314-97-8
- trimethylopropane tri(3-aziridinylpropanoate); (TAZ) CAS 52234-82-9
- trinickel disulphide;; nickel subsulfide [1]; heazlewoodite [2] CAS 12035-72-2[1]12035-7
- trisodium bis(7-acetamido-2-(4-nitro-2-oxidophenylazo)-3-sulphonato-1-naphtholato)chromate(1-) Index No 024-012-00-0
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Wording quoted from the regulation named above. Substance counts come from harmonised classifications in CLP Annex VI — the statements on a real product also depend on the supplier's own classification. Always check the supplier safety data sheet.