Substance profile
2-Methoxyaniline
2-Methoxyaniline is a yellowish liquid; becomes brownish on exposure to air with an amine-like odor.
01 · Identification
What 2-Methoxyaniline is
2-Methoxyaniline is a yellowish liquid; becomes brownish on exposure to air with an amine-like odor. Its molecular formula is C7H9NO and its molecular weight is 123.15 g/mol. It boils at 224 °C, melts at 6.2 °C, is miscible with water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
Other names for 2-Methoxyaniline
- o-anisidine
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H341 | Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
Precautionary statements: P201, P260, P270, P271, P280, P301, P302, P304, P308, P310, P313, P330, P352
03 · Physical and chemical properties
2-Methoxyaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 224 °C (435.2 °F) | HSDB | |
| 225 °C (437 °F) | NIOSH | ||
| 225 °C (437 °F) | at 760 mmHg | CAMEO | |
| Melting point | 6.2 °C (43.2 °F) | HSDB | |
| 5 °C (41 °F) | NIOSH | ||
| Density | 1.1 g/cm³ | NIOSH | |
| 1.0923 g/cm³ | at 20 °C | HSDB | |
| Solubility | Miscible with ethanol, benzene, diethyl ether and acetone | HSDB | |
| Soluble in ethanol, ethyl ether, acetone, benzene | HSDB | ||
| Soluble in dilute mineral acid, alcohol, and ether; insoluble in water | HSDB | ||
| Vapor pressure | 37.5031 mmHg | at 20 °C | ICSC |
| 0.08 mmHg | at 25 °C | HSDB | |
| 0.1 mmHg | below this value | NIOSH | |
| Flash point | 118 °C (244.4 °F) | open cup | HSDB |
| 117.78 °C (244 °F) | NIOSH | ||
| 98.89 °C (210 °F) | CAMEO | ||
| Autoignition temperature | 415 °C (779 °F) | HSDB | |
| 430 °C (806 °F) | ICSC | ||
| Lower explosive limit (LEL) | Not explosive | HSDB | |
| Class IIIB Combustible Liquid: Fl.P. at or above 200 °F. | NIOSH | ||
| Vapor density | 4.25 (air = 1) | HSDB | |
| 4.3 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling 2-Methoxyaniline
Storage conditions
Store in tightly closed containers in a cool, well ventilated area. Protect against sunlight and strong oxidizers. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ... /Anisidines/
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Incompatible with strong oxidizers, with risk of fire or explosions. Attacks some coatings and some forms of plastic and rubber. /Anisidines/
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
O-ANISIDINE is sensitive to heat. It is also sensitive to exposure to light. This chemical is incompatible with strong oxidizers. It is also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. It will attack some forms of plastics, rubber and coatings. (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2-Methoxyaniline in the storage compatibility matrix →