Substance profile
4-Chloroaniline
4-Chloroaniline is orthorhombic crystals from alcohol or petroleum ether with a slightly sweetish; characteristic amine odor.
01 · Identification
What 4-Chloroaniline is
4-Chloroaniline is orthorhombic crystals from alcohol or petroleum ether with a slightly sweetish; characteristic amine odor. Its molecular formula is C6H6ClN and its molecular weight is 127.57 g/mol. It boils at 232 °C, melts at 72.5 °C.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H311 | Toxic in contact with skin. |
| H301 | Toxic if swallowed. |
| H317 | May cause an allergic skin reaction. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Precautionary statements: P201, P260, P261, P270, P271, P272, P273, P280, P301, P302, P304, P308, P310, P313, P330, P333, P352, P391, P501
03 · Physical and chemical properties
4-Chloroaniline properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 232 °C (449.6 °F) | HSDB | |
| 232.22 °C (450 °F) | at 760 mmHg | CAMEO | |
| Melting point | 72.5 °C (162.5 °F) | HSDB | |
| Density | 1.4 g/cm³ | ICSC | |
| 1.43 g/cm³ | at 19 °C | CAMEO | |
| Solubility | Freely soluble in alcohol, ether, acetone, carbon disulfide | HSDB | |
| less than 1 mg/mL at 74.3 °F (NTP, 1992) | at 23.5 °C | CAMEO | |
| In water, 3,900 mg/L at 25 °C | at 25 °C | HSDB | |
| Vapor pressure | 0.015 mmHg | at 20 °C | CAMEO |
| 0.071 mmHg | at 25 °C | HSDB | |
| Flash point | 112.78 °C (235 °F) | CAMEO | |
| 121.5 °C (250.7 °F) | range, midpoint shown | ICSC | |
| Autoignition temperature | 685 °C (1265 °F) | ICSC | |
| Lower explosive limit (LEL) | 2.2 % by volume | CAMEO | |
| Vapor density | 4.41 (air = 1) | CAMEO | |
| 4.4 (air = 1) | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling 4-Chloroaniline
Storage conditions
Storage temperature: ambient.
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Very vigorous reactions may occur with strong oxidants.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
P-CHLOROANILINE is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid. (NTP, 1992)
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 4-Chloroaniline in the storage compatibility matrix →