Substance profile
O-Toluidine
O-Toluidine is a light yellow liquid becoming reddish brown on exposure to air and light with an aromatic aniline-like odor.
01 · Identification
What O-Toluidine is
O-Toluidine is a light yellow liquid becoming reddish brown on exposure to air and light with an aromatic aniline-like odor. Its molecular formula is C7H9N and its molecular weight is 107.15 g/mol. It boils at 200 °C, melts at -14.4 °C, is soluble in water.
Under the GHS it carries the signal word Danger. It is classed as hazardous Air Pollutants (HAPs).
Other names for O-Toluidine
- 2-aminotoluene
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H331 | Toxic if inhaled. |
| H301 | Toxic if swallowed. |
| H319 | Causes serious eye irritation. |
| H400 | Very toxic to aquatic life. |
Precautionary statements: P201, P260, P264, P270, P271, P273, P280, P301, P304, P305, P308, P310, P313, P330, P337, P338, P391, P501
03 · Physical and chemical properties
O-Toluidine properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 200.3 °C (392.5 °F) | HSDB | |
| 200 °C (392 °F) | NIOSH | ||
| Melting point | -14.41 °C (6.1 °F) | HSDB | |
| -23.7 °C (-10.7 °F) | alpha form | HSDB | |
| -14.44 °C (6 °F) | NIOSH | ||
| Density | 1.01 g/cm³ | NIOSH | |
| 0.9984 g/cm³ | at 20 °C | HSDB | |
| 0.998 g/cm³ | at 20 °C | CAMEO | |
| Solubility | Soluble in alcohol and ether | HSDB | |
| Miscible in ethanol, diethyl ether, carbon tetrachloride | HSDB | ||
| Soluble in dilute acids | HSDB | ||
| Vapor pressure | 0.3 mmHg | NIOSH | |
| 0.1 mmHg | at 20 °C | CAMEO | |
| 0.26 mmHg | at 25 °C | HSDB | |
| Flash point | 85 °C (185 °F) | HSDB | |
| Autoignition temperature | 482.22 °C (900 °F) | HSDB | |
| 480 °C (896 °F) | ICSC | ||
| Lower explosive limit (LEL) | 1.5 % by volume | HSDB | |
| Upper explosive limit (UEL) | 7.5 % by volume | HSDB | |
| Vapor density | 3.69 (air = 1) | HSDB | |
| 3.7 (air = 1) | ICSC | ||
| Odor threshold | Odor Threshold Low: 0.02 [ppm] | Haz-Map | |
| Odor Threshold High: 6.6 [ppm] | Haz-Map | ||
| Odor threshold from AIHA | Haz-Map | ||
| Critical temperature and pressure | 443.85 °C (830.9 °F) | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling O-Toluidine
Storage conditions
Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. o-Toluidine must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine) because violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where o-toluidine is used, handled, or stored in a manner that could creats a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ...
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Hypergolic reaction with red fuming nitric acid. Can react with oxidizing materials.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
O-TOLUIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Emits very toxic oxides of nitrogen when heated to decomposition. Undergoes a hypergolic reaction with red fuming nitric acid [Kit and Evered, 1960, p. 239, 242].
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check O-Toluidine in the storage compatibility matrix →