Substance profile
Ketoconazole
Ketoconazole is crystals from 4-methylpentanone.
01 · Identification
What Ketoconazole is
Ketoconazole is crystals from 4-methylpentanone. Its molecular formula is C26H28Cl2N4O4 and its molecular weight is 531.4 g/mol. It melts at 146 °C.
Under the GHS it carries the signal word Danger.
Other names for Ketoconazole
- 1-[4-[4-[[(2SR,4RS)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H360F | May damage fertility. |
| H301 | Toxic if swallowed. |
| H373 | May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Precautionary statements: P260, P270, P273, P301, P310, P314, P330, P391, P501
03 · Physical and chemical properties
Ketoconazole properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 146 °C (294.8 °F) | HSDB | |
| 150 °C (302 °F) | range, midpoint shown | ICSC | |
| Solubility | Solubility in water: none | ICSC | |
| 0.0866 mg/L | HMDB | ||
| Vapor pressure | Vapor pressure, Pa at 25 °C: (negligible) | at 25 °C | ICSC |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling Ketoconazole
Storage conditions
Store at controlled room temperature 15 deg - 25 °C (59 deg - 77 °F). Protect from moisture.
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Incompatible materials: Strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Planning storage for a mix of chemicals? Check Ketoconazole in the storage compatibility matrix →