Safety data sheet reference · CAS 101-68-8

Methylene diphenyl diisocyanate SDS

also: methylene diphenyl diisocyanate MSDS · safety data sheet · CAS 101-68-8 · EC 202-966-0[1]219-799- · MDI · 4,4'-MDI · diisocyanate

Danger Carc. 2 · Category 4 · STOT SE 3 · +5

Exclamation Mark GHS07 Health Hazard GHS08

Official PDF from supplier

Sigma-Aldrich ↗ Fisher Scientific ↗ Carl Roth ↗

This page is a reference, not the legal document.

CAS number

101-68-8

EC number

202-966-0[1]219-799-

CLP Annex VI index

615-005-00-9

§ 02 · Hazards identification

Harmonised EU classification

CLP Annex VI · Index 615-005-00-9. A supplier SDS may add self-classified hazards — this is the legal minimum.

H315 Causes skin irritation. Skin irritation — Category 2 (Skin Irrit. 2)

H317 May cause an allergic skin reaction. Skin sensitiser — Category 1 (Skin Sens. 1)

H319 Causes serious eye irritation. Eye irritation — Category 2 (Eye Irrit. 2)

H332 Harmful if inhaled. Acute toxicity, inhalation — Category 4

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. Respiratory sensitiser — Category 1 (Resp. Sens. 1)

H335 May cause respiratory irritation. Respiratory irritation — STOT SE 3

H351 Suspected of causing cancer. Carcinogenicity — Category 2 (Carc. 2)

H373 May cause damage to organs through prolonged or repeated exposure. STOT repeated exposure — Category 2 (STOT RE 2)

Precautionary statements

P201 Obtain special instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P264 Wash hands thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P271 Use only outdoors or in a well-ventilated area.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P302 IF ON SKIN: wash with plenty of water.

P304 IF INHALED: remove person to fresh air and keep comfortable for breathing.

P305 IF IN EYES: rinse cautiously with water for several minutes.

P308 IF exposed or concerned: get medical advice/attention.

P312 Call a POISON CENTER or doctor if you feel unwell.

P313 Get medical advice/attention.

P314 Get medical advice/attention if you feel unwell.

P332 If skin irritation occurs: get medical advice/attention.

P333 If skin irritation or rash occurs: get medical advice/attention.

P337 If eye irritation persists: get medical advice/attention.

P338 Remove contact lenses, if present and easy to do. Continue rinsing.

P352 Wash with plenty of water.

§ 07 · Handling and storage

Computed storage verdict

No storage segregation conflicts documented

Derived from CLP Annex VI classification and CAMEO reactive-group data — not copied from a PDF.

Full interactive verdict — reactions, gas release on contact, ADR forms →

§ 09 · Physical and chemical properties

Measured properties

Fire-relevant values first — flash point and explosion limits decide the storage and ventilation regime.

Flash point

218.3 °C

Melting point 37.2 °C

Relative density (water = 1) 1.2

Source: CAMEO Chemicals (NOAA, public domain); per-value source references stored in the database.

§ 10 · Stability and reactivity

Reactive group (CAMEO/NOAA): Isocyanates and Isothiocyanates. Our database documents 32 incompatible and 17 caution reaction-partner groups for methylene diphenyl diisocyanate — including which combinations release gas on contact. See the per-partner breakdown with gas release →

Incompatible

Caution

§ 13 · Disposal considerations

Dispose of waste and residues in accordance with local and national regulations — in the EU under the Waste Framework Directive 2008/98/EC. Never discharge to drains or municipal waste; hand contaminated packaging and unused product to an authorised waste-disposal company. The supplier's SDS section 13 lists the applicable waste codes for the specific product.

§ 14 · Transport information

Road transport — ADR 2025

UN number

UN 2206

Proper shipping name

ISOCYANATES, TOXIC, N.O.S. or ISOCYANATE SOLUTION, TOXIC, N.O.S.

Class · PG

6.1 · II

Classification code

Transport category

ADR labels

6.1

Hazard ID (Kemler) / UN plate

60

2206

Top: hazard identification number (Kemler). Bottom: UN number — as carried on the orange plate of the transport unit.

UN number

UN 2206

Proper shipping name

ISOCYANATES, TOXIC, N.O.S. or ISOCYANATE SOLUTION, TOXIC, N.O.S.

Class · PG

6.1 · III

Classification code

Transport category

ADR labels

6.1

Hazard ID (Kemler) / UN plate

60

2206

Top: hazard identification number (Kemler). Bottom: UN number — as carried on the orange plate of the transport unit.

Source: UN ADR 2025 (ECE/TRANS/352), Table A. Road (ADR) only — for sea (IMDG) and air (IATA), consult the supplier's SDS §14.

MSDS vs SDS

MSDS vs SDS: is there a difference?

MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the format is set by REACH Annex II. So a "methylene diphenyl diisocyanate MSDS" and a "methylene diphenyl diisocyanate SDS" refer to the same document — today it is issued as an SDS. Full breakdown of the differences →

Compliance hub

From classification to SDS

The classification above corresponds to Section 2 of a Safety Data Sheet. Learn how a compliant 16-section SDS is structured and authored →

GHS label maker

Build the label for methylene diphenyl diisocyanate

Pictograms, signal word and H-statements combined into a compliant label layout →

§ 16 · Sources

Classification: Regulation (EC) No 1272/2008 (CLP), Annex VI
Transport: UN ADR 2025 (UNECE), Table A
Reactivity: NOAA CAMEO Chemicals reactive-group matrix (public domain)
Physical properties: CAMEO Chemicals (NOAA, public domain) — per-value source references stored in the database
Substance data: PubChem · ECHA

Reference aid only. This page summarises the harmonised EU classification and computed storage guidance — it is not a Safety Data Sheet and does not replace one. Always verify hazards, handling and storage against the supplier's SDS (sections 7 and 10) and local regulations before use. Page updated 2026-07-27.

Frequently asked questions

Is an MSDS the same as an SDS?

In practice, yes. MSDS (Material Safety Data Sheet) is the older name for the same document. In the US, OSHA's Hazard Communication Standard (2012) adopted the GHS-standardised 16-section Safety Data Sheet; in the EU the SDS format is set by REACH Annex II. A document you find labelled "methylene diphenyl diisocyanate MSDS" is today issued as an SDS.

What GHS pictograms does methylene diphenyl diisocyanate require?

Under the harmonised EU classification (CLP Annex VI), methylene diphenyl diisocyanate carries GHS07 and GHS08 with the signal word "Danger". Hazard statements: H351, H332, H335, H373, H315, H319, H334, H317. A supplier's SDS may add self-classified hazards on top of this harmonised minimum.

Where can I download an official methylene diphenyl diisocyanate SDS PDF?

From your own supplier — an SDS is issued per product and supplier, so the correct PDF for an inspection is the one matching the product you actually purchased. The supplier links on this page lead to the official SDS libraries of major distributors.