Substance profile
Thioacetamide
Thioacetamide is crystals from benzene with slight odor of mercaptans.
01 · Identification
What Thioacetamide is
Thioacetamide is crystals from benzene with slight odor of mercaptans. Its molecular formula is C2H5NS and its molecular weight is 75.14 g/mol. It melts at 116 °C, is miscible with water.
Under the GHS it carries the signal word Danger. It is classed as carcinogens.
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H350 | May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H412 | Harmful to aquatic life with long lasting effects. |
Precautionary statements: P201, P264, P270, P273, P280, P301, P302, P305, P308, P312, P313, P330, P332, P337, P338, P352, P501
03 · Physical and chemical properties
Thioacetamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Melting point | 115.5 °C (239.9 °F) | DOE PAC | |
| 113.5 °C (236.3 °F) | range, midpoint shown | HSDB | |
| 113.06 °C (235.5 °F) | range, midpoint shown | CAMEO | |
| Solubility | In ethanol 26.4 g/100 g; sparingly sol in ether | HSDB | |
| Miscible in benzene | HSDB | ||
| MISCIBLE IN PETROLEUM ETHER | HSDB | ||
| Vapor pressure | 15.2 mmHg | Haz-Map | |
| Odor threshold | Medium odor threshold level: 94.7 ppm in 50% aqueous ethylene glycol. | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling Thioacetamide
Storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
FORMS COMPD & SULFIDES WITH SALTS OF HEAVY METALS; HYDROLYZED BY ACIDS OR BASES, FORMING ACETIC ACID, AMMONIA, NITROGEN & HYDROGEN SULFIDE
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
THIOACETAMIDE reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Thioacetamide in the storage compatibility matrix →