Substance profile
Acetamide
Acetamide is deliquescent hexagonal crystals and is odorless.
01 · Identification
What Acetamide is
Acetamide is deliquescent hexagonal crystals and is odorless. Its molecular formula is C2H5NO and its molecular weight is 59.07 g/mol. It boils at 222 °C, melts at 81.2 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
03 · Physical and chemical properties
Acetamide properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 222 °C (431.6 °F) | at 760 mmHg | HSDB |
| 221.11 °C (430 °F) | at 760 mmHg | CAMEO | |
| 222 °C (431.6 °F) | ICSC | ||
| Melting point | 81.16 °C (178.1 °F) | HSDB | |
| 82.28 °C (180.1 °F) | CAMEO | ||
| 81 °C (177.8 °F) | ICSC | ||
| Density | 1.16 g/cm³ | ICSC | |
| 1.159 g/cm³ | at 20 °C | HSDB | |
| Solubility | One gram dissolves in 0.5 mL water, 2 mL alcohol, 6 mL pyridine | HSDB | |
| Soluble in chloroform, glycerol, hot benzene | HSDB | ||
| In water, 7.05X10+5 mg/L at 24.5 °C | at 24.5 °C | HSDB | |
| Vapor pressure | 0.0182 mmHg | at 25 °C | HSDB |
| 1 mmHg | at 60 °C | DOE PAC | |
| 1 mmHg | at 65 °C | CAMEO | |
| Odor threshold | Recognition: 140-160 mg/cu m | HSDB |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Handling and storage
Storing and handling Acetamide
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive.
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Incompatible materials: Strong oxidizing agents, strong acids, strong bases, strong reducing agents.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
ACETAMIDE may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check Acetamide in the storage compatibility matrix →