Substance profile
2,4,6-Trichlorophenol
2,4,6-Trichlorophenol is crystals from ligroin with a strong phenolic odor.
01 · Identification
What 2,4,6-Trichlorophenol is
2,4,6-Trichlorophenol is crystals from ligroin with a strong phenolic odor. Its molecular formula is C6H3Cl3O and its molecular weight is 197.4 g/mol. It boils at 249 °C, melts at 69.5 °C.
Under the GHS it carries the signal word Warning. It is classed as hazardous Air Pollutants (HAPs).
02 · GHS classification
Hazards and label elements
Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.
| Code | Hazard statement |
|---|---|
| H351 | Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>. |
| H302 | Harmful if swallowed. |
| H315 | Causes skin irritation. |
| H319 | Causes serious eye irritation. |
| H400 | Very toxic to aquatic life. |
| H410 | Very toxic to aquatic life with long lasting effects. |
Precautionary statements: P201, P264, P270, P273, P280, P301, P302, P305, P308, P312, P313, P330, P332, P337, P338, P352, P391, P501
03 · Physical and chemical properties
2,4,6-Trichlorophenol properties
Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.
| Property | Value | Conditions | Source |
|---|---|---|---|
| Boiling point | 249 °C (480.2 °F) | HSDB | |
| 246.11 °C (475 °F) | at 760 mmHg | CAMEO | |
| 246 °C (474.8 °F) | ICSC | ||
| Melting point | 69.5 °C (157.1 °F) | HSDB | |
| 69 °C (156.2 °F) | ICSC | ||
| Density | 1.4901 g/cm³ | HSDB | |
| 1.675 g/cm³ | at 25 °C | CAMEO | |
| 1.7 g/cm³ | at 25 °C | ICSC | |
| Solubility | Soluble in ethanol, ethyl ether, acetic acid | HSDB | |
| In water, 500 mg/L at 25 °C | at 25 °C | HSDB | |
| Vapor pressure | 0.008 mmHg | at 25 °C | HSDB |
| 0.75 mmHg | at 71.8 °C | DOE PAC | |
| 1 mmHg | at 76.5 °C | CAMEO | |
| Flash point | 99 °C (210.2 °F) | ICSC | |
| Odor threshold | 100 ug/L at 30 °C; 1,222 ug/L at 25 °C | at 30 °C, Purity not specified | HSDB |
| Odor Threshold Low: 200.0 [ppm] | Haz-Map | ||
| Odor threshold (recognition) from CHEMINFO | Haz-Map |
Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.
04 · Source notes
Further notes on 2,4,6-Trichlorophenol
These are descriptions rather than measured values, so they are kept out of the table above and quoted here with the source that reported them.
Solubility
525 g/100 g acetone; 113 g/100 g benzene; 37 g/100 g carbon tetrachloride; 335 g/100 g diacetone alcohol; 400 g/100 g denatured alcohol formula; 525 g/100 g methanol; 163 g/100 g pine oil; 16 g/100 g Stoddard solvent; 100 g/100 g toluene; 37 g/100 g turpentine
Source: HSDB
05 · Handling and storage
Storing and handling 2,4,6-Trichlorophenol
Storage conditions
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/
Source: Hazardous Substances Data Bank (HSDB)
Incompatible materials
Incompatible materials: Strong oxidizing agents.
Source: Hazardous Substances Data Bank (HSDB)
Reactivity
2,4,6-TRICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. It can be converted to the sodium salt by reaction with sodium carbonate. Forms ethers, esters and salts by reaction with metals and amines. Undergoes substitution reactions such as nitration, alkylation, acetylation and halogenation. Can be hydrolyzed by reaction with bases at elevated temperatures and pressures. Reacts with alkalis at high temperatures (NTP, 1992).
Source: CAMEO Chemicals
Planning storage for a mix of chemicals? Check 2,4,6-Trichlorophenol in the storage compatibility matrix →