Provenance

Reference data from EU CLP Annex VI and published regulations — verify against your supplier's SDS before use.

Build a label

Substance profile

1,2-bis(2-methoxyethoxy)ethane

1,2-bis(2-methoxyethoxy)ethane: triethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor.

CAS 112-49-2 C8H18O4 178.23 g/mol Danger

01 · Identification

What 1,2-bis(2-methoxyethoxy)ethane is

1,2-bis(2-methoxyethoxy)ethane: triethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. Its molecular formula is C8H18O4 and its molecular weight is 178.23 g/mol. It boils at 216 °C, melts at -45 °C.

Under the GHS it carries the signal word Danger.

CAS number112-49-2
EC number203-977-3
Index number603-176-00-2
Molecular formulaC8H18O4
Molecular weight178.23 g/mol

Other names for 1,2-bis(2-methoxyethoxy)ethane

  • TEGDME
  • triethylene glycol dimethyl ether
  • triglyme

02 · GHS classification

Hazards and label elements

Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.

Signal wordDanger
Hazard statements assigned to 1,2-bis(2-methoxyethoxy)ethane
CodeHazard statement
H360Df May damage the unborn child. Suspected of damaging fertility.

Supplemental EU statements: EUH019

Precautionary statements: P201, P280, P308, P313

This page lists only the codes assigned to 1,2-bis(2-methoxyethoxy)et…. The full reference lives on the hazard statements hub, the precautionary statements hub and the GHS pictograms hub.

03 · Physical and chemical properties

1,2-bis(2-methoxyethoxy)ethane properties

Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.

Property Value Conditions Source
Boiling point 216.11 °C (421 °F) at 760 mmHg CAMEO
216 °C (420.8 °F) ICSC
216 °C (420.8 °F) at 760 mmHg DOE PAC
Melting point -45 °C (-49 °F) CAMEO
Density 0.99 g/cm³ ICSC
0.99 g/cm³ at 20 °C CAMEO
0.986 g/cm³ at 25 °C DOE PAC
Solubility Solubility in water: miscible ICSC
greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) at 21.11 °C CAMEO
Vapor pressure 0.9 mmHg at 20 °C CAMEO
0.9001 mmHg at 20 °C ICSC
0.04 mmHg Haz-Map
Flash point 111.11 °C (232 °F) CAMEO
111 °C (231.8 °F) ICSC
Autoignition temperature 630 °C (1166 °F) CAMEO
Vapor density 4.7 (air = 1) CAMEO
6.14 (air = 1) ICSC

Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.

04 · Handling and storage

Storing and handling 1,2-bis(2-methoxyethoxy)ethane

Reactivity

TRIETHYLENE GLYCOL DIMETHYL ETHER forms explosive peroxides on prolonged exposure to air. Its decomposition products may be sensitive to shock. The bulk chemical is stable for 2 weeks at temperatures up to 140 °F when protected from light. This chemical is incompatible with strong oxidizers. It is also incompatible with strong acids. It may react with peroxides, oxygen, nitric acid and sulfuric acid. (NTP, 1992).

Source: CAMEO Chemicals

Planning storage for a mix of chemicals? Check 1,2-bis(2-methoxyethoxy)e… in the storage compatibility matrix →

Safety Data Sheet

Getting an SDS for 1,2-bis(2-methoxyethoxy)et…

A Safety Data Sheet is written for a product, not for a substance: the supplier of the grade you actually buy issues it, so two suppliers of 1,2-bis(2-methoxyethox… issue two different sheets. That is why there is no single authoritative SDS for a substance to download — what there is, is the job of collecting the sheets for the products you hold and keeping them current as suppliers revise them.

Get the free GHS / CLP / OSHA deadline calendar

Verified 2026–2029 compliance dates in one PDF — plus alerts when the rules change.