Substance profile

Papaverine

Papaverine is white prisms from alcohol-diethyl ether; needles from petroleum ether.

CAS 58-74-2 C20H21NO4 339.4 g/mol Warning

01 · Identification

What Papaverine is

Papaverine is white prisms from alcohol-diethyl ether; needles from petroleum ether. Its molecular formula is C20H21NO4 and its molecular weight is 339.4 g/mol. It boils at 135 °C, melts at 148 °C.

Under the GHS it carries the signal word Warning.

CAS number58-74-2

EC number200-397-2

Index number614-018-00-7

Molecular formulaC20H21NO4

Molecular weight339.4 g/mol

02 · GHS classification

Hazards and label elements

Harmonised classification under CLP Annex VI. This is the legally binding classification in the EU; other jurisdictions may differ.

Exclamation mark

Signal wordWarning

Hazard statements assigned to Papaverine
Code	Hazard statement
H302	Harmful if swallowed.

Precautionary statements: P270, P301, P312, P330

03 · Physical and chemical properties

Papaverine properties

Every value is shown with the conditions it was measured under and the source it came from. Where sources disagree, all values are listed rather than one being picked — the difference is usually a different form of the substance, not an error.

Property	Value	Conditions	Source
Boiling point	135 °C (275 °F)	sublimes	HSDB
Melting point	147.5 °C (297.5 °F)		HSDB
	224.5 °C (436.1 °F)		HSDB
	226 (dec) °C		DrugBank
Density	1.337 g/cm³	at 20 °C	HSDB
Solubility	Slightly soluble in water; very soluble in ethanol, chloroform; soluble in acetone, benzene, pyridine		HSDB
	Almost insoluble in water. Soluble in hot benzene, glacial acetic acid, acetone; slightly soluble in chloroform, carbon tetrachloride, petroleum ether		HSDB
	In water, 35 mg/L at 17 °C	at 17 °C	HSDB

Values compiled from PubChem Laboratory Chemical Safety Summary. Temperatures converted to Fahrenheit for reference.

04 · Handling and storage

Storing and handling Papaverine

Storage conditions

Papaverine hydrochloride preparations should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the injection should be avoided. ...

Source: Hazardous Substances Data Bank (HSDB)

Planning storage for a mix of chemicals? Check Papaverine in the storage compatibility matrix →

Work with Papaverine

ATE mixture calculator Calculate acute toxicity estimate for a mixture containing this substance. Storage compatibility What this substance must not be stored next to. Label constructor Build a compliant GHS label with these pictograms and statements.